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SB 431542

SB 431542 구조식 이미지
카스 번호:
301836-41-9
상품명:
SB 431542
동의어(영문):
CS-89;SB 431542;SB 431542, >=98%;SB 431542 HYDRATE;SB-431542/SB431542;SB 431542USP/EP/BP;TGF-β RI Kinase Inhibitor VI, SB431542;InSolution? TGF-β RI Kinase Inhibitor VI, SB431542;4-(4-(Benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imid;SB 431542, 98%, a potent and selective inhibitor of ALK5
CBNumber:
CB5360318
분자식:
C22H16N4O3
포뮬러 무게:
384.39
MOL 파일:
301836-41-9.mol

SB 431542 속성

녹는점
214 °C(dec.)
끓는 점
662.4±55.0 °C(Predicted)
밀도
1.373
인화점
354.4℃
저장 조건
Sealed in dry,Store in freezer, under -20°C
용해도
DMSO: 10 mg/mL, soluble
물리적 상태
powder
산도 계수 (pKa)
10.14±0.10(Predicted)
InChIKey
FHYUGAJXYORMHI-UHFFFAOYSA-N

안전

안전지침서 22-24/25
WGK 독일 3
HS 번호 29349990

SB 431542 C화학적 특성, 용도, 생산

용도

SB 431542 is a known Src family kinase inhibitor that effectively blocks the transforming growth factor-β1-induced cell migration and invasion in both established and primary carcinoma cells.

정의

ChEBI: A member of the class of benzamides that is 4-(imidazol-2-yl)benzamide carrying additional 1,3-benzodioxol-5-yl and pyridin-2-yl substituents at positions 4 and 5 respectively on the imidazole ring.

생물학적 활성

Potent and selective inhibitor of the transforming growth factor- β (TGF- β ) type I receptor activin receptor-like kinase ALK5 (IC 50 = 94 nM), and its relatives ALK4 and ALK7. Suppresses TGF- β -induced proliferation of human osteosarcoma cells. Stimulates proliferation, differentiation and sheet formation of ESC-derived endothelial cells.

SB 431542 준비 용품 및 원자재

원자재

준비 용품


SB 431542 공급 업체

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