4-[(3-브로모페닐)아미노]-6-프로피오닐아미도퀴나졸린

4-[(3-브로모페닐)아미노]-6-프로피오닐아미도퀴나졸린
4-[(3-브로모페닐)아미노]-6-프로피오닐아미도퀴나졸린 구조식 이미지
카스 번호:
216163-53-0
한글명:
4-[(3-브로모페닐)아미노]-6-프로피오닐아미도퀴나졸린
동의어(한글):
4-[(3-브로모페닐)아미노]-6-프로피오닐아미도퀴나졸린
상품명:
4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINE
동의어(영문):
PD 174265;PD 174265 - CAS 216163-53-0 - Calbiochem;N-[4-(3-bromoanilino)quinazolin-6-yl]propanamide;4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINE;N-(4-((3-Bromophenyl)amino)quinazolin-6-yl)propionamide;Propanamide, N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-
CBNumber:
CB5381265
분자식:
C17H15BrN4O
포뮬러 무게:
371.23
MOL 파일:
216163-53-0.mol
MSDS 파일:
SDS

4-[(3-브로모페닐)아미노]-6-프로피오닐아미도퀴나졸린 속성

저장 조건
-20°C
용해도
DMF: 30 mg/ml; DMSO: 10 mg/ml; Ethanol: 1 mg/ml
물리적 상태
노란색 고체
색상
Light yellow to yellow

안전

4-[(3-브로모페닐)아미노]-6-프로피오닐아미도퀴나졸린 C화학적 특성, 용도, 생산

개요

PD 174265 is a potent, cell-permeable inhibitor of the tyrosine kinase activity of the epidermal growth factor (EGF) receptor (IC50 = 0.45 nM). It is effective in cells, blocking tyrosine phosphorylation induced by either EGF or heregulin (IC50s = 39 and 220 nM, respectively). The action of PD 174265 is reversible, which makes it a useful tool for comparative studies with irreversible inhibitors of EGFR kinase activity.

용도

PD 174265 is a potent, cell-permeable, reversible, and selective inhibitor of EGFR tyrosine kinase activity.

일반 설명

A potent, cell-permeable, reversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50 = 450 pM). The reversible nature of this compound makes it a less effective antitumor agent than PD 168393 (Cat. No. 513033).

효소 저해제

This substituted quinazoline (FWfree-base = 371.24 g/mol), also known as 4- [(3-bromophenyl)amino]-6-propionylamidoquinazoline, inhibits epidermal growth factor receptor (EGFR) protein-tyrosine kinase, IC50 = 0.45 nM. PD 174265 selectively targets and irreversibly inactivates the epidermal growth factor receptor tyrosine kinase through specific, covalent modification of a Cys-773. See also PD 168393

4-[(3-브로모페닐)아미노]-6-프로피오닐아미도퀴나졸린 준비 용품 및 원자재

원자재

준비 용품


4-[(3-브로모페닐)아미노]-6-프로피오닐아미도퀴나졸린 공급 업체

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