Anti-Nup98 antibody, Rat monoclonal

Anti-Nup98 antibody, Rat monoclonal 구조식 이미지
카스 번호:
상품명:
Anti-Nup98 antibody, Rat monoclonal
동의어(영문):
MONOCLONAL ANTI-NUP98;Anti-Nup98 antibody, Rat monoclonal
CBNumber:
CB54669510
분자식:
포뮬러 무게:
0
MOL 파일:
Mol file

Anti-Nup98 antibody, Rat monoclonal 속성

저장 조건
-20°C
물리적 상태
완충 수용액

안전

Anti-Nup98 antibody, Rat monoclonal C화학적 특성, 용도, 생산

용도

Anti-Nup98 antibody, Rat monoclonal may be used in:
  • enzyme linked immunosorbent assay (ELISA)
  • immunoblotting
  • immunocytochemistry

일반 설명

Monoclonal Anti-Nup98 (rat IgG2c- isotype) is derived from the hybridoma 2H10 produced by the fusion of mouse myeloma cells (SP2 cells) and splenocytes from WKY/NCrj rat immunized with a recombinant fragment of human Nup98. Nup96 and Nup98 are the nucleoporins that are formed by the cleavage of 186 kDa precursor protein.

Biochem/physiol Actions

Nup98 functions as a docking protein for cytosol mediated docking of import substrates. Securin protein damage caused by the anaphase-promoting complex (APC) during mitosis, is regulated by the nucleocytoplasmic transport factors Rae1 and Nup98. In mice, collective haploinsufficiency of Rae1 and Nup98 gene causes premature separation of sister chromatids and severe aneuploidy. In addition, it also leads to untimely degradation of securin. Chromosome rearrangement between the HOXA9 (homeobox A9) gene and the nucleoporin gene Nup98 has been observed in some human myeloid leukemia patients.

Anti-Nup98 antibody, Rat monoclonal 준비 용품 및 원자재

원자재

준비 용품


Anti-Nup98 antibody, Rat monoclonal 공급 업체

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