9-히드록시플루오렌
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9-히드록시플루오렌 속성
- 녹는점
- 153-154 °C(lit.)
- 끓는 점
- 275.62°C (rough estimate)
- 밀도
- 1.0368 (rough estimate)
- 굴절률
- 1.5994 (estimate)
- 저장 조건
- Sealed in dry,Room Temperature
- 용해도
- 클로로포름(약간 용해됨), 메탄올(약간 용해됨)
- 물리적 상태
- 결정성 분말
- 산도 계수 (pKa)
- 13.34±0.20(Predicted)
- 색상
- 크림색
- 수용성
- 물에 불용성.
- BRN
- 1869799
- 안정성
- 안정적인. 타기 쉬운. 강한 산화제와 호환되지 않습니다.
- CAS 데이터베이스
- 1689-64-1(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi | ||
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위험 카페고리 넘버 | 36/37/38 | ||
안전지침서 | 24/25-36/37/39-27-26 | ||
유엔번호(UN No.) | UN 3077 9/PG III | ||
WGK 독일 | 3 | ||
위험 참고 사항 | Irritant | ||
TSCA | Yes | ||
위험 등급 | 9 | ||
포장분류 | III | ||
HS 번호 | 29062990 |
9-히드록시플루오렌 C화학적 특성, 용도, 생산
화학적 성질
white powder용도
9-Fluorenol is used in Organic Synthesis, Pharmaceuticals, Agrochemicals and Dyestuffs.정의
ChEBI: 9-Fluorenol is a member of the class of hydroxyfluorenes that is 9H-fluorene substituted by a hydroxy group at position 9 (the non-aromatic carbon). It has a role as an animal metabolite. It is a member of hydroxyfluorenes and a secondary alcohol.주요 응용
9-Fluorenol is a wake-promoting agent and is considered a next-generation anti-drowsiness drug. It is also a potential environmental carcinogen.9-Fluorenol is a dopamine reuptake inhibitor with IC50 of 9 μM, and a major metabolite of a compound developed as a wakefulness-promoting agent.
제조 방법
Synthesis of 9-Fluorenol: A 5-g sample of 9-fluorenone is dissolved in 30 mL of warm ethanol in a 100-mL beaker. To this solution is added, dropwise, 10 mL of a reducing reagent, freshly prepared, which consists of 200 mg sodium methoxide,10 mL methanol, and 0.4 g sodium borohydride.This solution is allowed to stand undisturbed for 10-20 min. A color change is observed as the reaction proceeds from the yellow 9-fluorenone to the white 9-fluorenol.The product is precipitated by the addition of 50 mL of water and neutralized with 0.1 M HCl, vacuum filtered, and washed with cold water to remove any residual inorganic salt formed by the excess of the sodium borohydride reagent and hydrochloric acid.The dried crude product is sufficiently pure for characterization by melting point, infrared spectra,and NMR.The crude product melting point is 153°C, with a product yield of 95-100%.A Synthesis of 9-Fluorenol: Sodium Borohydride Reduction of 9-Fluorenone
Synthesis
9-Fluorenol is prepared by reacting 9-fluorenone with THF solution of phosphazene under the action of boron catalyst.Add 9-fluorenone (0.8 mmol), a 0.2 M THF solution of phosphazene (80 μL, 0.016 mmol) and a 0.0762 M THF solution of boron catalyst (420 μL, 0.032 mmol) to a scintillation vial with magnetic stir bar in a glove box. Place the scintillation vial in a Parr reactor. Seal the reactor. Pressurize the reactor with hydrogen gas. Heat reaction mixture at 75°C (inside the reactor). Stir the reaction mixture (1000 rpm) for 20 hours at 75°C. Cool the mixture to room temperature and vent the Parr reactor to obtain 9-hydroxyfluoren. Analyze the reaction mixture by 1H NMR spectroscopy using CDCl3 as solvent.Fig the synthetic method of 9-Fluorenol
9-히드록시플루오렌 준비 용품 및 원자재
원자재
준비 용품
9-히드록시플루오렌 공급 업체
글로벌( 313)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Wuhan Nutra Biotechnology Co.,Ltd | +8617786394783 |
nutrabiotech@outlook.com | China | 300 | 58 |
Zepeptide Biotechnology (Shijiazhuang) Co., Ltd | +86-86-13383293380 +8613230482270 |
1919301810@qq.com | China | 141 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12446 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 5873 | 58 |
Hubei Chuyan Biopharmaceutical Co., Ltd | +1-027-87896938 +15172028168 |
chuyan@chuyan.co | China | 24 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20293 | 58 |
Hebei Mojin Biotechnology Co.,Ltd | +86-15028179902 |
angelia@hbmojin.com | China | 1069 | 58 |
Springchem New Material Technology Co.,Limited | +86-021-62885108 +8613917661608 |
info@spring-chem.com | China | 2068 | 57 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 18629 | 58 |
9-히드록시플루오렌 관련 검색:
9-히드록시-9-플루오렌카르복실산 9-히드록시플루오렌 플루오렌 2-히드록시플루오렌
2-Bromo-9-phenyl-9H-fluoren-9-ol
2-AMINO-9-FLUORENOL
9-ETHYNYL-9-FLUORENOL
FLURENOL-METHYL ESTER
Flurenol-butyl
Chlorflurecol
9-phenyl-9H-9-fluorenol,9-PHENYL-9-FLUORENOL
Chlorflurenol-methyl
2,7-Dibromo-9-phenyl-9H-fluoren-9-ol
9-FLUORENYL ACETATE
9-HYDROXYFLUORENE-9-CARBOXYLIC ACID
9-TRIFLUOROMETHYL-9H-FLUOREN-9-OL
5,6-dihydrofluoranthen-6a(4H)-ol
1-FLUORENOL