CRAC Channel Inhibitor III, Pyr6 - Calbiochem C화학적 특성, 용도, 생산
일반 설명
A cell-permeable pyrazole derivative that acts as a selective blocker of Stim1 and Orai1-coupled CRAC (Ca2+ release-activated Ca2+) channel-mediated SOCE (store-operated Ca2+ entry) in RBL-2H3 cells (IC50 = 490 nM by Fura-2; peak current density pA/pF = -1.31 and -7.50, respectively, with or without 3 μM Pyr6 by whole cell clamp), while exhibiting much reduced potency against the transient receptor potential cation channel TRPC3-medated ROCE (receptor-operated Ca2+ entry) upon carbachol (Cat. No. 212385) stimulation in TRPC3-expressing HEK293 cells (IC50 = 18.46 μM; by Fura-2; pA/pF = -9.50 and -18.50, respectively, with or without 3 μM Pyr6). A great complement to Pyr2 (Cat. No. 203890), Pyr3 (Cat. No. 648490), and Pyr10 (Cat. No. 648494) in Ca2+ signaling studies.
Biochem/physiol Actions
Cell permeable: yes
CRAC Channel Inhibitor III, Pyr6 - Calbiochem 준비 용품 및 원자재
원자재
준비 용품
CRAC Channel Inhibitor III, Pyr6 - Calbiochem 공급 업체