NKY80;AKOS B003518;VITAS-BB TBB000019;SALOR-INT L203769-1EA;Adenylyl Cyclase Type V Inhibitor, NKY80;2-amino-7-(2-furyl)-7,8-dihydroquinazolin-5(6H)-one;2-AMINO-7-(FURANYL)-7,8-DIHYDRO-5(6H)-QUINAZOLINONE;2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONE;2-Amino-7-(2-furanyl)-7,8-dihydro-5(6H)-quinazolinone;2-Amino-7-(furan-2-yl)-7,8-dihydroquinazolin-5(6H)-one
2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONE C화학적 특성, 용도, 생산
용도
NKY 80 is an inhibitor of adenylyl cyclase (AC) and displays a greater affinity for AC5 over AC3 and AC2. Adenyl cyclase inhibitors can be easily modified by tumor targeting structures.
일반 설명
A cell-permeable quinazolinone containing a non-nucleoside compound that acts as a potent, selective inhibitor of adenylyl cyclase (AC) type V isoform (IC50 = 8.3 μM, 132 μM and 1.7 mM for type V, III and II, respectively) in the presence of Gsα GTPγS-Forskolin. Displays ~210-fold greater selectivity for type V over the type II isoform. The inhibition is non-competitive with respect to ATP and Forskolin. Regulates the AC catalytic activity in heart and lung tissues.
Biochem/physiol Actions
Cell permeable: yes
2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONE 준비 용품 및 원자재
원자재
준비 용품
2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONE 공급 업체
