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cis-4-Hydroxy-L-proline

cis-4-Hydroxy-L-proline 구조식 이미지
카스 번호:
618-27-9
상품명:
cis-4-Hydroxy-L-proline
동의어(영문):
CHYP;cis L;CIS-HYP-OH;H-CIS-HYP-OH;cis-L-Hyp-OH;H-L-CIS-HYP-OH;(2S,4S)-(−cis-4-Hydroxy-L;CIS-HYDROXYPROLINE;H-PRO(CIS-4-OH)-OH
CBNumber:
CB6158895
분자식:
C5H9NO3
포뮬러 무게:
131.13
MOL 파일:
618-27-9.mol

cis-4-Hydroxy-L-proline 속성

녹는점
257 °C (dec.) (lit.)
끓는 점
242.42°C (rough estimate)
알파
-59 º (c=2, H2O)
밀도
1.3121 (rough estimate)
굴절률
-59 ° (C=2, H2O)
저장 조건
Keep in dark place,Sealed in dry,Room Temperature
용해도
soluble
물리적 상태
Powder
산도 계수 (pKa)
2.14±0.40(Predicted)
색상
White to beige
수용성
soluble
Merck
14,4840
BRN
81440
InChIKey
PMMYEEVYMWASQN-IMJSIDKUSA-N
CAS 데이터베이스
618-27-9(CAS DataBase Reference)
EPA
L-Proline, 4-hydroxy-, (4S)- (618-27-9)

안전

위험품 표기 Xi
위험 카페고리 넘버 36/37/38
안전지침서 24/25-36/37/39-27-26
WGK 독일 3
F 고인화성물질 10
TSCA Yes
HS 번호 29339900

cis-4-Hydroxy-L-proline MSDS


cis-4-Hydroxy-L-proline

cis-4-Hydroxy-L-proline C화학적 특성, 용도, 생산

화학적 성질

White to beige powder

용도

Hydroxyprolines are valuable chiral building blocks for organic synthesis of pharmaceuticals. Several microorganisms producing proline trans-4- and cis-3-hydroxylase were discovered and these enzymes were applied to the industrial production of trans-4- and cis-3-hydroxy-L-proline.

용도

cis-4-Hydroxy-L-proline (CHP) is a proline analog that inhibits collagen synthesis and has been used as an anticancer compound. CHP blocked myotube formation and expression of sarcomeric myosin heavy chain in C2C12 murine skeletal muscle cells. CHP inhibited proliferation of murine Panc02 pancreatic carcinoma cell line3 and rat pancreatic carcinoma cell line DSL6A. cis-4-Hydroxy-L-proline and other hydrosyl-L-prolines are important intermediates for chiral synthesis of potential drugs.

정의

ChEBI: L-Proline in which a hydrogen at the 4-position of the pyrrolidine ring is substituted by a hydroxy group (S-configuration).

cis-4-Hydroxy-L-proline 준비 용품 및 원자재

원자재

준비 용품


cis-4-Hydroxy-L-proline 공급 업체

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Chengdu Pukang Biotechnology Co., Ltd
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export@pu-kang.com CHINA 210 58
Changzhou Ditong Chemical Co.,Ltd
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info@edengenechem.com CHINA 2124 58
Hubei xin bonus chemical co. LTD
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027-59338440 linda@hubeijusheng.com CHINA 23035 58

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