N-Tosyl-5-bromo-4,7-diazaindole
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N-Tosyl-5-bromo-4,7-diazaindole 속성
- 끓는 점
- 499.6±55.0 °C(Predicted)
- 밀도
- 1.68±0.1 g/cm3(Predicted)
- 저장 조건
- under inert gas (nitrogen or Argon) at 2-8°C
- 산도 계수 (pKa)
- -2.22±0.30(Predicted)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
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| 유해·위험 문구: |
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| 예방조치문구: |
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N-Tosyl-5-bromo-4,7-diazaindole C화학적 특성, 용도, 생산
제조 방법
A solution of anhydrous DMF (272 mL) dissolved with 2-bromo-5H-pyrrolo[2,3-b]pyrazine (78.0 g, 394 mmol) was configured. The temperature is maintained at 0-5 °C (within which the subsequent reaction has been maintained), and the solution was droppedly added to the sodium (12.8 g, 532 mmol) anhydrous DMF (543 mL) suspension in the stirred state within 60 minutes. The solution turned brown and the reaction solution was stirred for about 30 min. Then, within 60 minutes, anhydrous DMF (272 mL) dissolved with p-toluenesulfonyl chloride (94.0 g, 492 mmol) was added. After stirring the mixed solution for about 1 h, it was heated to ambient temperature and stirred for about 18 h. Slowly pour the reaction mixture into ice water (6 L) and added 2.5 N NaOH in water (50.0 mL, 125 mmol). Filter the sediment to collect and stirred 3 times with cold water (200 mL). Finally, the collected products were filtered and dried to a constant weight in a vacuum oven at about 55 °C to obtain N-Tosyl-5-bromo-4,7-diazaindole (134.6 g, 97%).
참고 문헌
[1] Yael Ross, Marina Magrey, Use of upadacitinib in the treatment of psoriatic arthritis, Immunotherapy, 2021, 13.[2] Lina Serhal, Christopher J Edwards, Upadacitinib for the treatment of rheumatoid arthritis, Expert Review of Clinical Immunology, 2018, 15,13-25.
[3] Eleni Kotsiliti, Upadacitinib therapy for Crohn’s disease, Nature Reviews Gastroenterology & Hepatology, 2023, 20, 483.
N-Tosyl-5-bromo-4,7-diazaindole 준비 용품 및 원자재
원자재
5-Bromo-4,7-diazaindole
5-[(4-methylphenyl)sulfonyl]-5H-Pyrrolo[2,3-b]pyrazin-2-amine
5-bromo-3-((trimethylsilyl)ethynyl)pyrazin-2-amine
파라-톨루엔설폰일 염화물
준비 용품
N-Tosyl-5-bromo-4,7-diazaindole 공급 업체
글로벌( 162)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Golden Pharma Co., Limited | +undefined18958062155 |
sales@zjgoldpharm.com | China | 5905 | 58 |
| Hangzhou ICH Biofarm Co., Ltd | +undefined8613073685410 |
sales@ichemie.com | China | 985 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 7934 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
| Anhui Dexinjia Biopharm Co., Ltd | +86-531-82375818 +86-15064153060 |
alice@jndxj.com | China | 309 | 58 |
| Accela ChemBio Inc. | (+1)-858-699-3322 |
info@accelachem.com | United States | 19965 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63711 | 58 |
| Shanghai Jinghao Pharmaceutical Co.,Ltd | +86-21-68900963 |
sales@jinghaopharma.com | CHINA | 153 | 58 |
| Shanghai Yingrui Biopharma Co.,Ltd | 21-33585366 |
export01@shyrchem.com | CHINA | 1320 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; |
factory@coreychem.com | China | 29826 | 58 |
N-Tosyl-5-bromo-4,7-diazaindole 관련 검색:
1-Pyrrolidinecarboxylic acid, 3-(2-bromoacetyl)-4-ethyl-, phenylmethyl ester, (3S,4S)-
1-Pyrrolidinecarboxylic acid, 3-[2-[(ethoxycarbonyl)[5-[(4-methylphenyl)sulfonyl]-5H-pyrrolo[2,3-b]pyrazin-2-yl]amino]acetyl]-4-ethyl-, phenylmethyl ester, (3S,4S)-
1-Pyrrolidinecarboxylic acid, 3-(2-chloroacetyl)-4-ethyl-, phenylmethyl ester, (3R,4S)-
INDEX NAME NOT YET ASSIGNED
5-Bromo-4,7-diazaindole