눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
NFPA 704
0
2
0
MIBEFRADIL C화학적 특성, 용도, 생산
개요
Posicor was launched in Argentina, Azerbaijan, Brazil, the Chile, Czech
Republic, Denmark, Germany, Ireland, Kazakhstan, the Netherlands, Norway, Peru,
the Philippines, Switzerland, Thailand, Turkmenistan, the UK, the US and Venezuela
for use in hypertension. It can be assembled in five steps from 4-(1-benzyloxy-Nmethylformamido)
butyric acid with o-phenylenediamine and isobutylchloroformate.
Posicor binds to calcium channels in a manner that overlaps the Verapamil, SR-33557
and Diltiazem binding site without effecting the dihydropyridine binding site. Thus it
blocks a wide variety of calcium channels with selectivity for T-type followed
sequentially by L-type. There is also some calcium agonist activity along with sodium
and potassium channel activity. It is chemically distinct from the other calcium
antagonists (first member of a new catagory of tetralol calcium antagonists). It has the
ability to lower heart rate with no negative inotropic effects and is as effective as
Amlodipine and more effective than Diltiazem for the treatment of mild to moderate
hypertension. Serious drug interactions are possible because Posicor inhibits both
CYP2D6 and CYP3A4.
용도
Mibefradil has been used as a T-type calcium channel blocker in various cells. It has also been used to reduce apoptosis of retinal ganglion cells (RGC) in EphB2-Fc.
