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ELLIPTICINE

ELLIPTICINE 구조식 이미지

카스 번호:: 519-23-3

상품명:: ELLIPTICINE

동의어(영문):: K00071;icig770;CP-3025;LP00531;CS-1794;CCG36483;NSC-71795;CCG 36483;CCG-36483;DB-052047

CBNumber:: CB6746832

분자식:: C17H14N2

포뮬러 무게:: 246.31

MOL 파일:: 519-23-3.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 110

ELLIPTICINE 속성

녹는점: 316-318°C

끓는 점: 379.31°C (rough estimate)

밀도: 1.257±0.06 g/cm3 (20 ºC 760 Torr)

굴절률: 1.5794 (estimate)

저장 조건: Keep in dark place,Sealed in dry,2-8°C

용해도: DMSO: 용해될 수 있다

물리적 상태: 밝은 노란색 고체

산도 계수 (pKa): 16.59±0.40(Predicted)

Merck: 13,3581

LogP: 4.800

CAS 데이터베이스: 519-23-3(CAS DataBase Reference)

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

위험품 표기	T
위험 카페고리 넘버	25
안전지침서	45
유엔번호(UN No.)	UN 3462 6.1/PG 3
WGK 독일	3
RTECS 번호	UU8825000
위험 등급	6.1(b)
포장분류	III
독성	LD50 in mice (mg/kg): 19.5-22.4 i.v.; 178-204 orally (Rakieten)

그림문자(GHS):

신호 어:

Danger

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	그림 문자	P- 코드
H301	삼키면 유독함	급성 독성 물질 - 경구	구분 3	위험		P264, P270, P301+P310, P321, P330,P405, P501

예방조치문구:

P264	취급 후에는 손을 철저히 씻으시오.
P264	취급 후에는 손을 철저히 씻으시오.
P270	이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P301+P310	삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.
P405	밀봉하여 저장하시오.
P501	...에 내용물 / 용기를 폐기 하시오.

ELLIPTICINE C화학적 특성, 용도, 생산

개요

Ellipticine is an alkaloid isolated from Apocyanaceae plants that exhibits antitumor activities by intercalating into DNA and/or inhibiting DNA topoisomerase II. It forms covalent adducts in DNA after being enzymatically activated with cytochrome P450 isoforms (e.g., CYP3A4, CYP1A1, or CYP1A2) or by peroxidases in target tissues. Ellipticine has been shown to inhibit the proliferation of human breast adenocarcinoma MCF-7 cells, leukemia HL-60 and CCRF-CEM cells, neuroblastoma IMR-32, UKF-NB-3, and UKF-NB-4 cells, and U87MG glioblastoma cells with IC₅₀ values ranging from 0.27-4.7 μM.

정의

ChEBI: A organic heterotetracyclic compound that is pyrido[4,3-b]carbazole carrying two methyl substituents at positions 5 and 11.

일반 설명

A topoisomerase II inhibitor. Acts as an intercalative alkaloid that stimulates topoisomerase II-mediated DNA breakage. Is also capable of uncoupling mitochondrial oxidative phosphorylation.

Purification Methods

This DNA intercalator is purified by recrystallisation from CHCl3 or MeOH and is dried in vacuo. The UV max values in aqueous EtOH/HCl are at 241, 249, 307, 335 and 426nm. [Marini-Bettolo & Schmutz Helv Chim Acta 42 2146 1959.] The methiodide has m 360o(dec), with UV (EtOH/KOH) at 223, 242, 251, 311, 362 and 432nm. [Goodwin et al. J Am max Chem Soc 81 1903 1959, Beilstein 23/9 V 417.]

ELLIPTICINE 준비 용품 및 원자재

원자재

준비 용품

ELLIPTICINE 공급 업체

글로벌( 110)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3012	60
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3620	58
Xi'an Kono chem co., Ltd.,	029-86107037 13289246953	info@konochemical.com	China	2995	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Finetech Industry Limited	+86-27-87465837 +8618971612321	info@finetechnology-ind.com	China	9702	58
Alfa Chemistry	+1-5166625404	Info@alfa-chemistry.com	United States	21317	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58

ELLIPTICINE 관련 검색:

ELLIPTICINE Ellipticine acetomethylate N,N-diethyl-N'-(9-methoxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazol-1-yl)propane-1,3-diamine 9-methoxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazole 9-hydroxy-2,5,11-trimethyl-6H-pyrido[4,3-b]carbazolium iodide 5,11-dimethyl-6H-pyrido[4,3-b]carbazol-9-ol 5-(hydroxymethyl)-11-methyl-6H-pyrido(4,3-b)carbazole N-methylcarbamate ELLIPTICINE(REAGENT / STANDARD GRADE) Ellipticine, 9-Hydroxy-, HCl 8-nitroellipticine detalliptinium 9-aminoellipticine 9-METHOXY-2-METHYLELLIPTICINIUM ACETATE HYDRATE 5,11-Dimethyl-9-methoxy-N-propyl-6H-pyrido(4,3-b)carbazol-1-amine male ate ELLIPTICINE, 9-HYDROXY-, HYDROCHLORIDE 5,11-Dimethyl-N-ethyl-9-methoxy-6H-pyrido(4,3-b)carbazol-1-amine malea te 5,11-Dimethyl-9-methoxy-6H-pyrido(4,3-b)carbazol-1-amine maleate 1-((3-(Diethylamino)propyl)amino)-5,11-dimethyl-6H-pyrido(4,3-b)carbaz ol-9-ol