눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P330
입을 씻어내시오.
P391
누출물을 모으시오.
P501
...에 내용물 / 용기를 폐기 하시오.
NFPA 704
0
2
0
4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile C화학적 특성, 용도, 생산
개요
In May 2011, the U.S. FDA approved rilpivirine in combination with other
antiretroviral agents for the treatment of human immunodeficiency virus
(HIV) 1 infection in treatment-naive adult patients.
Rilpivirine is a member of the nonnucleoside reverse transcriptase inhibitor (NNRTI) class of anti-HIV
agents. It is highly potent against a range of wild-type HIV strains
(EC50=0.07–1.0 nM),～10–20 timesmore potent than the NNRTI efavirenz
(Sustiva), and active against HIV strains resistant to other NNRTIs. The
discovery of rilpivirine was guided by molecular modeling and X-ray
crystallography of HIV-1 RT complexed with inhibitors. The synthesis
of rilpivirine is accomplished by an efficient 6-step route in which the key
step is coupling of 4-((4-chloropyrimidin-2-yl)amino)benzonitrile with (E)-3-(4-amino-3,5-dimethylphenyl)acrylonitrile.
화학적 성질
N/ABright Yellow Solid
정의
ChEBI: An aminopyrimidine that is pyrimidine-2,4-diamine in which the amino groups at positions 2 and 4 are substituted by 4-cyanophenyl and 4-[(E)-2-cyanovinyl]-2,6-dimethylphenyl groups respectively. Used for treatment of HIV.
4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile 준비 용품 및 원자재
원자재
준비 용품
4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile 공급 업체
