Ripasudil hydrochloride dihydrate

Ripasudil hydrochloride dihydrate 구조식 이미지
카스 번호:
887375-67-9
상품명:
Ripasudil hydrochloride dihydrate
동의어(영문):
K-115 HCL;K 115; K115;K115 HCL 2H2O;K-115 (HCl H2O);Ripasudil (K-115);K115 HCl Dihydrate;Ripasudil free base;K 155 HCl dihydrate;RipasudilHCl Hydrate;Ripasudil HCl Dihydrate
CBNumber:
CB52667596
분자식:
C15H21ClFN3O3S
포뮬러 무게:
377.86
MOL 파일:
887375-67-9.mol

Ripasudil hydrochloride dihydrate 속성

저장 조건
Store at -20°C
용해도
insoluble in EtOH; ≥123.2 mg/mL in DMSO; ≥41.7 mg/mL in H2O
물리적 상태
고체
물리적 상태
단단한 모양
안정성
흡습성

안전

위험 카페고리 넘버 24/25-26-28
안전지침서 28-38-41-48
HS 번호 29339900

Ripasudil hydrochloride dihydrate C화학적 특성, 용도, 생산

개요

Ripasudil hydrochloride hydrate (Glanatec®) was approved in Japan in 2014 for the treatment of glaucoma and ocular hypertension. Originally discovered by D. Western Therapeutics Institute, Inc. and licensed by the Kowa Company, Ltd, ripasudil functions as a selective Rho-kinase inhibitor and reduces intraocular pressure by stimulation of aqueous humour drainage of the trabecular meshwork. While this recent approval allows for use of ripasudil as a twice-daily monotherapy treatment when other drugs cannot be used or are not effective, clinical trials using ripasudil as a combination therapy with other glaucoma drugs have shown promising results in the treatment of primary open-angle glaucoma or ocular hypertension. Currently, the Kowa Company is also pursuing trials focused on the use of ripasudil for the treatment of diabetic retinopathy and diabetic macular edema.

용도

Ripasudil Hydrochloride Dihydrate is a derivative of fasudil and a rho kinase inhibitor (1,2). It is used for the treatment of glaucoma and ocular hypertension.

Ripasudil hydrochloride dihydrate 준비 용품 및 원자재

원자재

준비 용품


Ripasudil hydrochloride dihydrate 공급 업체

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