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(S,R,S)-AHPC-PEG3-Alkyne

(S,R,S)-AHPC-PEG3-Alkyne 구조식 이미지

카스 번호:: 2374122-30-0

상품명:: (S,R,S)-AHPC-PEG3-Alkyne

동의어(영문):: (S,R,S)-AHPC-PEG3-Alkyne;(S,R,S)-AHPC-PEG?-Alkyne;(S,R,S)-AHPC-PEG₃-Alkyne;(2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-7,10,13-trioxa-3-azahexadec-15-ynoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;(2S,4R)-1-[(2S)-3,3-dimethyl-2-(3-{2-[2-(prop-2-yn-1-yloxy)ethoxy]ethoxy}propanamido)butanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide;(2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-7,10,13-trioxa-3-azahexadec-15-ynoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, Crosslinker–E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader, VH032 conjugate

CBNumber:: CB84846305

분자식:: C32H44N4O7S

포뮬러 무게:: 628.79

MOL 파일:: 2374122-30-0.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 13

(S,R,S)-AHPC-PEG3-Alkyne 속성

끓는 점: 881.7±65.0 °C(Predicted)

밀도: 1.224±0.06 g/cm3(Predicted)

저장 조건: 2-8°C

산도 계수 (pKa): 14.07±0.40(Predicted)

물리적 상태: powder or crystals

안전

(S,R,S)-AHPC-PEG3-Alkyne C화학적 특성, 용도, 생산

용도

Protein degrader builiding block (S,R,S)-AHPC-PEG4-Alkyne enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant alkyne for click chemistry with an azide on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant alkyne group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

(S,R,S)-AHPC-PEG3-Alkyne 준비 용품 및 원자재

원자재

준비 용품

(S,R,S)-AHPC-PEG3-Alkyne 공급 업체

글로벌( 13)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Xian confluore Biological Technology Co., Ltd.	+86-15680926068	1924344760@confluore.cn	China	2997	58
Aladdin Scientific		tp@aladdinsci.com	United States	52923	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51395	80
ShangHai Biochempartner Co.,Ltd	177-54423994 17754423994	2853530910@QQ.com	China	8000	62
Xi'an Confluore Biological Technology Co., Ltd.	+86-156-80926068 +86-15680926068	1924344760@qq.com	China	4952	58
Jilin Province Woda Biotechnology Co., Ltd.	13504435624	1927928688@qq.com	China	1615	58
Shanghai Haohong Pharmaceutical Co., Ltd.	400-8210725 4008210725	malulu@leyan.com	China	55000	58
Zhengzhou convergence chemical co., LTD	0371-0371-55153829 18003835034	2853979819@qq.com	China	9998	58
Shanghai Yanbang Pharmaceutical Technology Co., Ltd	15618536883	1228181347@qq.com	China	7951	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054;	trendseenbio@gmail.com	China	9069	58