4-Nitrophthalonitrile

4-Nitrophthalonitrile 속성

4-Nitrophthalonitrile MSDS

5-Nitrobenzene-1,2-dicarbonitrile

4-Nitrophthalonitrile C화학적 특성, 용도, 생산

화학적 성질

light yellow, light greenish or light grey to

용도

4-Nitrophthalonitrile is a useful chemical in organic synthesis. Dyes and metabolites.

제조 방법

Synthesis of 4-Nitrophthalonitrile: SOCl2 (83.5 mL. 1.144 mol) was added dropwise under nitrogen purge to dry DMF (200 mL) which had been cooled to 0-5 °C. The solution was allowed to stir for 15 min at 0-5 °C. The 4-nitrophthalamide (60.1 g, 0.286 mol) was then added and the solution was allowed to slowly warm to room temperature and react for 18 h under nitrogen purge. The solution was then slowly added to ice water to crystallize and precipitate the product. The 4-nitrophthalonitrile was collected using vacuum filtration, washed with ice cold water, and allowed to air dry overnight; yield: 45.2 g (92%); m.p.: 141 °C (det. by DSC)
1 H NMR((CD3)2SO): 8.41 (dd, 1H), 8.67 (dd, 1H), 9.03 (dd, 1H) FTIR: 3091 (m, aromatic C-H stretch), 2242 (d, CN stretch), 1534 (s, asymmetric N=O stretch), 1349 (s, symmetric N=O stretch), 853 (s, C-N stretch)

Synthesis

4-Nitrophthalonitrile synthesized from phthalimide in three steps. The reaction time of ruthenium chloride and HZSM-5 catalysts was very shorter than ammonium molybdate and Hβ catalysts. The yield while we used ruthenium chloride and HZSM-5 catalysts were very higher than another.

In a three necked flask, 70 mL of dry dimethylformamide (DMF) was cooled to 0 °C under a stream of nitrogen and 7.3 mL of thionyl chloride was added so that the internal temperature did not go beyond 5 °C. After addition, nitrogen flow was ceased and a calcium chloride tube was added to the top of flask. Meanwhile, the color of the medium was observed to be yellow. Then, 10 g (0.048 mol) of 4- nitrophthalamide was slowly added so that the internal temperature did not go beyond 5 °C. The mixture was stirred over ice bath for 1 hour. The mixture was stirred at room temperature for 2 hours and then poured over 500 g of ice-water. The precipitate was filtered and washed successively with water, 250 mL 5% sodium hydrogencarbonate solution, and water again and dried in a vacuum oven at 110-120 °C. Molecular formula: C8H3N3O2. Yield: 7.4 g (90%). Mp: 141 °C.

4-Nitrophthalonitrile 준비 용품 및 원자재

원자재

준비 용품

4-Nitrophthalonitrile 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Hubei XinghengKang Chemical Technology Co., Ltd.	027-88878869 18162384755	xhkhu2014@163.com	China	240	58
Shanghai Taijilin Industrial Co., Ltd.	02150630626 17717886015	kate@tajilin.com	China	1342	58
Jinan Dexinjia Bio&Tech Co., Ltd	0531-82375818 15064153060	1329217348@qq.com	China	1446	58
Nantong Xiaochang Pharmaceutical Trading Co., Ltd.	0513-82104991 18862997351	sales11@btcpharm.com	China	859	58
Jiangsu 01 Industrial Co., Ltd	0523-87653988 15105181882	519181683@qq.com	China	131	58
Changsha Changtang Import and Export Co., LTD	19310125487 19310125487	1761256297@qq.com	China	995	58
SHANDONG XINGRUNDA CHEMICAL CO.,LTD	0534-18615348689 18615348689	hclt1978@163.com	China	35	58
Shanghai Boyle Chemical Co., Ltd.	021-50182298 021-50180596	sales@boylechem.com	China	2202	55
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Changzhou Sunchem Pharmaceutical Chemical Material Co.,Ltd.	0519-85195575 15861192208;15861192208;13685253038	850305@sunkechem.com	China	69	69

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