4-Nitrophthalonitrile
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4-Nitrophthalonitrile 속성
- 녹는점
- 142-144 °C(lit.)
- 끓는 점
- 303.75°C (rough estimate)
- 밀도
- 1.4553 (rough estimate)
- 굴절률
- 1.6500 (estimate)
- 저장 조건
- Sealed in dry,Room Temperature
- 물리적 상태
- 결정질 분말, 결정 및/또는 덩어리
- 색상
- 밝은 노란색, 밝은 녹색 또는 밝은 회색에서 베이지색
- 수용성
- 물에 난용성.(0.26 g/L) (25°C),
- BRN
- 1877554
- CAS 데이터베이스
- 31643-49-9(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 22-36/37/38-20/21/22 | ||
안전지침서 | 26-36 | ||
WGK 독일 | 3 | ||
RTECS 번호 | TI8576000 | ||
TSCA | Yes | ||
HS 번호 | 29269090 | ||
독성 | mouse,LD50,oral,500mg/kg (500mg/kg),SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTIONBEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION,Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 52(9), Pg. 92, 1987. |
4-Nitrophthalonitrile C화학적 특성, 용도, 생산
화학적 성질
light yellow, light greenish or light grey to용도
4-Nitrophthalonitrile is a useful chemical in organic synthesis. Dyes and metabolites.제조 방법
Synthesis of 4-Nitrophthalonitrile: SOCl2 (83.5 mL. 1.144 mol) was added dropwise under nitrogen purge to dry DMF (200 mL) which had been cooled to 0-5 °C. The solution was allowed to stir for 15 min at 0-5 °C. The 4-nitrophthalamide (60.1 g, 0.286 mol) was then added and the solution was allowed to slowly warm to room temperature and react for 18 h under nitrogen purge. The solution was then slowly added to ice water to crystallize and precipitate the product. The 4-nitrophthalonitrile was collected using vacuum filtration, washed with ice cold water, and allowed to air dry overnight; yield: 45.2 g (92%); m.p.: 141 °C (det. by DSC)1 H NMR((CD3)2SO): 8.41 (dd, 1H), 8.67 (dd, 1H), 9.03 (dd, 1H) FTIR: 3091 (m, aromatic C-H stretch), 2242 (d, CN stretch), 1534 (s, asymmetric N=O stretch), 1349 (s, symmetric N=O stretch), 853 (s, C-N stretch)
Synthesis
4-Nitrophthalonitrile synthesized from phthalimide in three steps. The reaction time of ruthenium chloride and HZSM-5 catalysts was very shorter than ammonium molybdate and Hβ catalysts. The yield while we used ruthenium chloride and HZSM-5 catalysts were very higher than another.In a three necked flask, 70 mL of dry dimethylformamide (DMF) was cooled to 0 °C under a stream of nitrogen and 7.3 mL of thionyl chloride was added so that the internal temperature did not go beyond 5 °C. After addition, nitrogen flow was ceased and a calcium chloride tube was added to the top of flask. Meanwhile, the color of the medium was observed to be yellow. Then, 10 g (0.048 mol) of 4- nitrophthalamide was slowly added so that the internal temperature did not go beyond 5 °C. The mixture was stirred over ice bath for 1 hour. The mixture was stirred at room temperature for 2 hours and then poured over 500 g of ice-water. The precipitate was filtered and washed successively with water, 250 mL 5% sodium hydrogencarbonate solution, and water again and dried in a vacuum oven at 110-120 °C. Molecular formula: C8H3N3O2. Yield: 7.4 g (90%). Mp: 141 °C.
4-Nitrophthalonitrile 준비 용품 및 원자재
원자재
1H-Isoindol-1-one, 3-hydroxy-
1,2-벤젠디카르보닐이염화물,4-니트로-
3-Nitrophthalonitrile
4-니트로프탈디아미드
4-Nitrophthalimide
1,2-벤젠다이카보나이트릴
4-나이트로프탈산
준비 용품
4-Nitrophthalonitrile 공급 업체
글로벌( 514)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Asia Chem I and E (Jiangsu) Co Ltd | +8615105181882 |
mera.z@nitrobenzenechemical.com | China | 129 | 58 |
Chengdu Yuanda Chemical Co., Ltd | 28-85356300 +8618980937689 |
sales@ydachem.com | CHINA | 94 | 58 |
Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 |
info@dycnchem.com | China | 52861 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 5873 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5892 | 58 |
Firsky International Trade (Wuhan) Co., Ltd | +8615387054039 |
admin@firsky-cn.com | China | 436 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20291 | 58 |
ShenZhen H&D Pharmaceutical Technology Co., LTD | +8618627948422 |
sale@hdimpurity.com | China | 3389 | 58 |
Hebei Mojin Biotechnology Co.,Ltd | +86-15028179902 |
angelia@hbmojin.com | China | 1085 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
4-Nitrophthalonitrile 관련 검색:
4-나이트로프탈산 이소프탈로니트릴 3-아미노벤조나이트릴 4-아미노벤조니트릴 1,2-벤젠다이카보나이트릴
Febuxostat Impurity 8
4-(2-Methylpropoxy)-1,3-benzenedicarbothioaMide
isopropyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate
ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE
ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate
3-Cyano-4-isobutoxybenzoic acid
FeBuxostat Impurity 33
Febuxostat impurity 37
Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate
Febuxostat-d9
2-[3-(AMinocarbonyl)-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylic Acid
2-[3-Carboxy-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylic Acid
2-HYDROXY-THIOBENZAMIDE