1.4-다이옥세인
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1.4-다이옥세인 속성
- 녹는점
- 12 °C
- 끓는 점
- 101 °C
- 밀도
- 1.034 g/mL at 25 °C(lit.)
- 증기 밀도
- 3 (vs air)
- 증기압
- 27 mm Hg ( 20 °C)
- 굴절률
- n
20/D 1.422(lit.)
- 인화점
- 54 °F
- 저장 조건
- room temp
- 용해도
- Soluble in acetone, alcohol, benzene, and ether (Weast, 1986). Miscible with most organic solvents (Huntress and Mulliken, 1941) including 2-methylpropanol, toluene, cychexanone, and cyclopentanone.
- 물리적 상태
- 액체
- 색상
- APHA: ≤20
- 냄새
- 0.8~172ppm(평균 = 12ppm)에서 약한 에테르 같은 냄새가 감지됩니다.
- 수소이온지수(pH)
- 6-8 (500g/l, H2O, 20℃)
- 폭발한계
- 1.7-25.2%(V)
- 수용성
- 녹는
- 감도
- Hygroscopic
- 최대 파장(λmax)
- λ: 220 nm Amax: ≤0.70
λ: 235 nm Amax: ≤0.50
λ: 250 nm Amax: ≤0.20
λ: 270 nm Amax: ≤0.10
λ: 295-400 nm Amax: ≤0.01
- Merck
- 14,3300
- BRN
- 102551
- Henry's Law Constant
- 4.89(x 10-6 atm?m3/mol) (static headspace-GC, Welke et al., 1998)
- 노출 한도
- TLV-TWA 25 ppm (≈90 mg/m3) (ACGIH), 100 ppm (MSHA and OSHA); carcinogenicity: Animal Sufficient Evidence (IARC).
- Dielectric constant
- 2.2(25℃)
- 안정성
- 안정적인. 산화제, 산소, 할로겐, 환원제, 습기와 호환되지 않습니다. 가연성이 높음 - 폭발 범위가 넓습니다. 보관 시 폭발성 과산화물을 형성할 수 있습니다(가열, 증발 또는 빛에 노출되면 형성 속도가 증가함).
- InChIKey
- RYHBNJHYFVUHQT-UHFFFAOYSA-N
- LogP
- -0.42 at 20℃
- CAS 데이터베이스
- 123-91-1(CAS DataBase Reference)
- IARC
- 2B (Vol. 11, Sup 7, 71) 1999
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn,F,T | ||
---|---|---|---|
위험 카페고리 넘버 | 45-46-11-36/38-48/23/24/25-65-66-40-36/37-19-41-37/38-39/23/24/25-23/24/25-48/20/22-38-22-36/37/38-10 | ||
안전지침서 | 9-16-36/37-46-45-53-7-62-26-24/25-23-S9-S46-S36/37-S16 | ||
유엔번호(UN No.) | UN 1993 3/PG 2 | ||
WGK 독일 | 3 | ||
RTECS 번호 | JG8225000 | ||
F 고인화성물질 | 8 | ||
자연 발화 온도 | 180 °C | ||
TSCA | Yes | ||
위험 등급 | 3 | ||
포장분류 | II | ||
HS 번호 | 29329990 | ||
유해 물질 데이터 | 123-91-1(Hazardous Substances Data) | ||
독성 | LD50 in mice, rats (ml/kg): 5.7, 5.2 orally (Laug) | ||
IDLA | 500 ppm | ||
기존화학 물질 | KE-10463 |
1.4-다이옥세인 C화학적 특성, 용도, 생산
용도
유기용매에 모두 잘 녹는 우수한 용제이며, 공업적으로 아세틸셀룰로스나 에틸셀룰로스의 용제, 또 도료용 용제 등으로 널리 쓰이고 있다.개요
1,4-dioxane is a clear liquid with ether-like odour. It is highly flammable and forms explosive peroxides in storage (rate of formation increased by heating, evaporation, or exposure to light). 1,4-Dioxane is incompatible with oxidising agents, oxygen, halogens, reducing agents, and moisture. Industrial applications of 1,4-dioxane are extensive, for instance, as solvent for cellulose acetate, ethyl cellulose, benzyl cellulose, resins, oils, waxes, and some dyes; as a solvent for paper, cotton, and textile processing; and for various organic and inorganic compounds and products. It is also used in automotive coolant liquid and in shampoos and other cosmetics as a degreasing agent and as a component of paint and varnish. Human exposures to 1,4-dioxane have been traced to multiple occupations and breathing of contaminated workplace air and drinking polluted water. Industrial uses of 1,4-dioxane are very many. For instance, it is used as solvent for celluloses, resins, lacquers, synthetic rubbers, adhesives, sealants, fats, oils, dyes, and protective coatings; as a stabiliser for chlorinated solvents and printing inks; and as a wetting and dispersing agent in textile processing agrochemicals and pharmaceuticals, in different processing of solvent-extraction processes, and in the preparation and manufacture of detergents.화학적 성질
1,4-Dioxane is a colorless, stable liquid with a faint, pleasant odor. Although it has been known as far back as 1863, it was not until 1929 that is became commercially available. It is chemically a di-ether obtained by the loss of water from two molecules of ethylene glycol. It is completely soluble in water, as well as most organic solvents. It is freely soluble in mineral, vegetable, blown and heat-bodied oils, and oil soluble dyes. Most waxes are more readily soluble in dioxane when heated and examples of these are beeswax, carnauba, montan, paraffin, gilsonite, and Japan wax.물리적 성질
Clear, colorless, very flammable, volatile liquid with a faint pleasant, ether-like odor. Experimentally determined detection and recognition odor threshold concentrations were 2.9 mg/m3 (800 ppbv) and 6.5 mg/m3 (1.8 ppmv), respectively (Hellman and Small, 1974).용도
1,4-Dioxane, the six-member cyclic diether, is used as an aluminum inhibitor in chlorinated solvents like 1,1,1-trichloroethane and as a solvent for certain resins and polymers.정의
ChEBI: A dioxane with oxygen atoms at positions 1 and 4.일반 설명
A clear colorless liquid with a faint ethereal odor. Flash point 55°F. Slightly denser than water and soluble in water. Vapors heavier than air. Susceptible to autooxidation to form peroxides.공기와 물의 반응
Highly flammable. When exposed to air 1,4-Dioxane undergoes autooxidation with formation of peroxides. In the distillation process peroxides will concentrate causing violent explosion. Water soluble.반응 프로필
1,4-Dioxane is a flammable liquid; when exposed to air 1,4-Dioxane undergoes autooxidation with formation of peroxides. In the distillation process peroxides will concentrate causing violent explosion. The addition complex with sulfur trioxide (1:1) sometimes decomposes violently on storing at room temperature [Sisler, H. H. et al., Inorg. Synth., 1947, 2, p. 174]. Evaporation of boron trifluoride in aqueous 1,4-Dioxane with nitric acid led to an explosion upon addition of perchloric acid [MCA Guide, 1972, p. 312]. Explosive reaction with Raney nickel catalyst above 210° C {Mozingo R., Org. Synth., 1955, Coll. Vol. 3, p. 182].건강위험
The toxicity of 1,4-dioxane is low in testanimals by all routes of exposure. However,in humans the toxicity of this compoundis severe. The target organs are theliver, kidneys, lungs, skin, and eyes. Exposureto its vapors as well as the absorptionthrough the skin or ingestion can cause poisoning,the symptoms of which include drowsiness,headache, respiratory distress, nausea,and vomiting. It causes depression of centralnervous system. There are reports of humandeaths from subacute and chronic exposures todioxane vapors at concentration levels rangingbetween 500 and 1000 ppm. Serious healthhazards may arise from its injurious effects onthe liver, kidneys, and brain. Rabbits died ofkidney injury resulting from repeated inhalationof 1,4-dioxane vapors for 30 days (Smyth1956). It is an irritant to the eyes, nose, skin,and lungs. In humans, a 1-minute exposure to5000-ppm vapors can cause lacrimation.LC50 value, inhalation (rats): 13,000 ppm/2 h
LD50 value, oral (mice): 5700 mg/kg
1,4-Dioxane is an animal carcinogen oflow potential. Ingestion of high concentrationsof this compound at a level of7000–18,000 ppm in drinking water for14–23 months caused nasal and liver tumorsin rats (ACGIH 1986). Guinea pigs developedlung tumors.
인화성 및 폭발성
Dioxane is a highly flammable liquid (NFPA rating = 3). Its vapor is heavier than air and may travel a considerable distance to a source of ignition and flash back. Dioxane vapor forms explosive mixtures with air at concentrations of 2 to 22% (by volume). Fires involving dioxane should be extinguished with carbon dioxide or dry powder extinguishers.Dioxane can form shock- and heat-sensitive peroxides that may explode on concentration by distillation or evaporation. Samples of this substance should always be tested for the presence of peroxides before distilling or allowing to evaporate. Dioxane should never be distilled to dryness.
Safety Profile
Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenicdata. Poison by intraperitoneal route. Moderately toxic by ingestion and inhalation. Mildly toxic by skin contact. Human systemic effects by inhalation: lachrymation, conjunctiva irritation, convulsions, hgh blood pressure, unspecified respiratory and gastrointestinal system effects. Mutation data reported. An eye and slun irritant. The irritant effects probably provide sufficient warning, in acute exposures, to enable a worker to leave exposure before being seriously affected. Repeated exposure to low concentrations has resulted in human fatahties, the organs chefly affected being the liver and kidneys. A very dangerous fire and explosion hazard when exposed to heat or flame; can react vigorously with oxidizing materials. Violent reaction with (H2 + Raney Ni), AgClO4. Can form dangerous peroxides when exposed to air. Potentially explosive reaction with nitric acid + perchloric acid, Raney nickel catalyst (above 210°C). Forms explosive mixtures with decaborane (impactsensitive), triethynylaluminum (sensitive to heating or drying). Violent reaction with sulfur trioxide. Incompatible with sulfur trioxide. To fight fire, use alcohol foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes. See also GLYCOL ETHERS.Carcinogenicity
1,4-Dioxane is reasonably anticipated to be a human carcinogen basedon sufficient evidence of carcinogenicity from studies in experimental animals.저장
dioxane should be used only in areas free of ignition sources, and quantities greater than 1 liter should be stored in tightly sealed metal containers in areas separate from oxidizers. Containers of dioxane should be dated when opened and tested periodically for the presence of peroxides.비 호환성
Dioxane can form potentially explosive peroxides upon long exposure to air. Dioxane may react violently with Raney nickel catalyst, nitric and perchloric acids, sulfur trioxide, and strong oxidizing reagents.폐기물 처리
Excess dioxane and waste material containing this substance should be placed in an appropriate container, clearly labeled, and handled according to your institution's waste disposal guidelines.주의 사항
Workers Should be careful during handling of 1,4-Dioxane and avoid open flames, sparks and smoking. Workers should wear proper protectives since 1,4-Dioxane in known as hazardous, cause damage to eyes, respiratory tract, liver and kidney.1.4-다이옥세인 준비 용품 및 원자재
원자재
준비 용품
EMITEFUR
BOC-D-Alanine
BOC-D-Phenylalanine
N-T-BOC-Β-ALANINE
6-N-HEPTYLMERCAPTOPURINE
8-Hydroxyquinoline-2-carboxaldehyde
Dirithromycin
polyurethane polysiloxane copolymer
6-Aminouracil
PILSICAINIDE
N-Acetylethylenediamine
1,3-dihydroxy-2-naphthoic acid
N-BOC-piperidine-4-carboxylic acid
Boc-O-benzyl-L-tyrosine
아스파라진
γ-L-glutamyl-1-naphthylamide
FMOC-O-tert-Butyl-L-serine
FMOC-O-tert-Butyl-L-threonine
N-(tert-Butoxycarbonyl)-L-phenylalanine
Levosimendan
4-Methyl-5-thiazolylethyl acetate
Fmoc-Tyr(tBu)-OH
2,4,5-Trifluorophenylacetic acid
Quinoline-7-carbaldehyde
5-Bromouracil
2-히드록시-1-나프토산
2-HYDROXY-4-PYRIDINECARBOXALDEHYDE
N-tetradecyl glycine sodium salt
2-Phenylquinoline
4-(Trifluoromethyl)phenacyl bromide
3-Phenyl-1H-pyrazole
Boc-Thr(Bzl)-OH
BOC-Glycine
HPG
BENZYL 1-HOMOPIPERAZINECARBOXYLATE
3-METHYL-4-PYRIDINECARBOXALDEHYDE
카타라세
9-(Chloromethyl)anthracene
디에틸스틸베스트롤
Oxyfedrine
1.4-다이옥세인 공급 업체
글로벌( 719)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Jinan Chengyuan Chemical Co. , Ltd. | +86-0531-88274992 +8615552568189 |
2408152070@qq.com | China | 10 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12456 | 58 |
Hebei Dangtong Import and export Co LTD | +8615632927689 |
admin@hbdangtong.com | China | 991 | 58 |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 |
deasea125996@gmail.com | China | 2503 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 7845 | 58 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 15928 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9348 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 |
info@tnjchem.com | China | 2989 | 55 |