셀레콕시브

셀레콕시브 C화학적 특성, 용도, 생산

Originator

Celact,Sun Pharmaceuticals Industries Ltd.,India

Manufacturing Process

4-(5-(4-Methylphenyl)-3-trifluoromethyl-N-pyrazol-1-yl)benzenesulfonamide To a solution of ethyl trifluoroacetate (1.90 ml, 16.0 mmol) in 7 ml of methyl tert-butyl ether was added 25% NaOMe (3.62 ml, 16.8 mmol). Next 4- chloroaceteophenone (2.08 ml, 16.0 mmol) in 2 ml of methyl tert-butyl ether was added. The mixture was stirred at room temperature overnight. To above solution was added 100 ml of 90% EtOH, followed by 4 N HCl (4.0 ml, 16 mmol) and 4-sulphonamidophenylhydrazine hydrochloride (3.58 g, 16 mmol). The mixture was heated to reflux for 3 hours. The mixture was concentrated. When 30 ml of water was added, a solid formed. The solid was filtered and washed with 20 ml of 60% EtOH to give 4.50 g of white solid. The filtrate was evaporated and taken up in ethyl acetate (100 ml), washed with saturated NaHCO3, and brine, dried over MgSO4, and concentrated. Heptane was added at boiling point of the mixture. After cooling down to 0°C, 1.01 g more product was obtained. The combined yield of the 4-(5-(4-methylphenyl)-3- trifluoromethyl-N-pyrazol-1-yl)benzenesulfonamide (Celecoxib) was 86%.

Therapeutic Function

Antiinflammatory

셀레콕시브 준비 용품 및 원자재

원자재

준비 용품

셀레콕시브 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Alfa Chemistry	+1-5166625404	Info@alfa-chemistry.com	United States	21317	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418684 +8618949823763	sales@tnjchem.com	China	25363	58
ZHEJIANG JIUZHOU CHEM CO., LTD	+86-0576225566889 +86-13454675544	admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com	China	19947	58
Changzhou AniKare Pharmatech Co., Ltd.	+86-0519-8359-8696 +8618018249389	sales@anikare.com	China	8478	58
China Nobel Chem Co., Limited	+86(0)21 60484900		China	764	50
Credit Asia Chemical Co., Ltd.	+86 (21) 61124340		China	9767	58
Nanjing crow LuNing pharmaceutical technology co., LTD	13382066392		CHINA	4880	58
Shanghai Han-Xiang Chemical Co., Ltd.	15971444841	amber@biochempartner.com	China	3063	58
Wuhan kemike Biomedical Technology Co., Ltd	027-13163388153 13163388153	yeqiu416@163.com	China	9974	58
Zhongxin Chenshi (Wuhan) Technology Co., Ltd	18942922096	2662561040@qq.com	China	1002	58