상태
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상태 속성
- 녹는점
- 209 °C
- 알파
- D15 -20° (c = 0.64 in water)
- 끓는 점
- 306.53°C (rough estimate)
- 밀도
- 1.1233 (rough estimate)
- 굴절률
- 1.4476 (estimate)
- 저장 조건
- 2-8°C
- 용해도
- 0.5 M HCl: 50mg/mL, 투명하고 매우 희미한 노란색
- 산도 계수 (pKa)
- 3.97±0.10(Predicted)
- 물리적 상태
- Solid
- 색상
- White to off-white
- Merck
- 13,8879
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
그림문자(GHS): | |||||||||||||||||||||||||||||
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신호 어: | Warning | ||||||||||||||||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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상태 C화학적 특성, 용도, 생산
화학적 성질
white powderClinical Use
With the possible exception of atorvastatin, the statins are used to lower LDL cholesterol in familial or polygenic ( multifactorial) hypercholesterolemia (type IIa) and in combination with triglyceride-lowering drugs to treat combined hyperlipidemia (type IIb) when both LDL and VLDL (very low density lipoproteins) are elevated. However, the statins probably should not be given with the fibrates (triglyceridelowering drugs, discussed later), since this combination may greatly increase statin toxicity. Atorvastatin, the most potent of the available statins, has also been shown to lower blood triglycerides significantly.This effect may be due to decreasing hepatic cholesterol and cholesterol ester levels to such an extent that hepatic formation of VLDL is impaired.The statins also have been claimed to reduce blood cholesterol levels modestly in some patients with homozygous familial hypercholesterolemia, a condition often fatal in childhood or in early adulthood.
The statins may lower the risk of CHD by decreasing inflammation, an important component of atherogenesis. Lovastatin decreased elevated plasma levels of Creactive protein, a marker for cellular inflammation, and acute coronary events in patients with relatively low plasma cholesterol levels. Recent studies also suggest that use of statins may decrease the risk of stroke, dementia, and Alzheimer’s disease and may improve bone density in postmenopausal women. These broad actions may be related to the hypocholesterolemic, antiproliferative, antiinflammatory, or antioxidant properties of the statins or some combination of these properties.
부작용
The statins generally appear to be well tolerated, with muscle pain and liver dysfunction seen in 1 to 2% of patients. However, the consequences of 20 to 30 years of continuous use are unknown. This fact has been dramatically reinforced by the recent recognition of a potentially fatal consequence of statin use. A relatively common side effect of the statins (perhaps 1% of patients) is myositis, that is, inflammation of skeletal muscle accompanied by pain, weakness, and high levels of serum creatine kinase. Rhabdomyolysis, i.e., disintegration of muscle with urinary excretion of myoglobin and kidney damage, was considered to be a rare and extreme toxic outcome. However, cerivastatin (Baycol) has now been withdrawn from the market by its manufacturer (Bayer) because of 31 deaths linked to fatal rhabdomyolysis. The risk of muscle damage is said to increase with simultaneous use of the triglyceride-lowering fibrates. Pravastatin may be less toxic than other statins because it does not readily penetrate extrahepatic cells and may be more confined to the liver after oral dosage.상태 준비 용품 및 원자재
원자재
Pentanal, 2-[bis(phenylmethyl)amino]-4-methyl-, (2S)-
Heptanoic acid, 3-hydroxy-6-methyl-4-[[(phenylmethoxy)carbonyl]amino]-, (3S,4S)-
5-메틸-헥스-2-에노산에틸에스테르
이소밸러알데히드
준비 용품
상태 공급 업체
글로벌( 65)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 |
laboratory@coreychem.com | China | 30250 | 58 |
BOC Sciences | 16314854226; +16314854226 |
inquiry@bocsci.com | United States | 19743 | 58 |
Nextpeptide Inc | +86-0571-81612335 +8613336028439 |
sales@nextpeptide.com | China | 19915 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 |
market18@leapchem.com | China | 43348 | 58 |
Beijing Ouhe Technology Co., Ltd | 010-82967028 13552068683 |
2355560935@qq.com | China | 12439 | 60 |
Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 |
info@hanhongsci.com | China | 42959 | 64 |
Chemsky (shanghai) International Co.,Ltd | 021-50135380 |
shchemsky@sina.com | China | 15421 | 60 |
SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD | 13816107857 |
sales@fortunechem-sh.com | China | 289 | 58 |
MedChemexpress LLC | 021-58955995 |
sales@medchemexpress.cn | United States | 4863 | 58 |
상태 관련 검색:
펩스타틴 A
Propynol ethoxylate
ACETYL-PEPSTATIN
6-METHYLHEPTANOIC ACID
CHA-STATINE
FMOC-LEU-STATINE,N-ALPHA-FMOC-L-STATINE,N-FMOC-L-STATINE,FMOC-STATINE,(3S,4S)-N-(9-FLUORENYLMETHYLOXYCARBONYL)-STATINE
BOC-CHA-STATINE
ISOVALERYL-VAL-VAL-STA-OET
FMOC-CHA-STATINE
ISOVALERYL-PHE-NLE-STA-ALA-STA-OH
PEPSINOSTREPTIN
STATINE
BOC-PHE-STATINE
renin inhibitory peptide, statine
BOC-EPI-STATINE,(3R,4S)-N-TERT-BUTYLOXYCARBONYL-STATINE
FMOC-PHE-STATINE
BOC-STATINE,BOC-LEU-STATINE,N-T-BOC-STATINE,N-tert-butoxycarbonyl statine,(3S,4S)-N-TERT-BUTYLOXYCARBONYL-STATINE
(3s,4s)-4-amino-3-hydroxy-6-methylheptanoic acid(Statine)