눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P332+P313
피부 자극이 생기면 의학적인 조치· 조언을 구하시오.
P337+P313
눈에 대한 자극이 지속되면 의학적인 조치· 조언를 구하시오.
P370+P378
화재 시 불을 끄기 위해 (Section 5. 폭발, 화재시 대처방법의 적절한 소화제)을(를) 사용하시오.
P403+P235
환기가 잘 되는 곳에 보관하고 저온으로 유지하시오.
B-benzo[b]naphtho[2,3-d]furan-2-yl-boronic acid C화학적 특성, 용도, 생산
용도
B-benzo[b]naphtho[2,3-d]furan-2-yl-boronic acid can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
Synthesis
12.6g of intermediate (A) and 500 mL of tetrahydrofuran (dehydrated) were put in a flask, and the resultant
was cooled to -78??C. 28 mL of n-BuLi (1.60M in hexane) was added, and stirring was conducted for 2 hours while
elevating the temperature to 0??C. Then, the solution was again cooled to -78??C, and 11.6g of B(OMe) 3 was added. After
stirring at 10 minutes at -78??C, stirring was further conducted for 5 hours while gradually elevating the temperature to
room temperature. After completion of the reaction, 1 N HCl aq. (100 mL) was added, and the reaction solution was stirred at room
temperature for 1 hour. Then, the solution was transferred to a separating funnel, and extracted with ethyl acetate. This solution was dried with MgSO 4, concentrated and washed with hexane, whereby 7.2g (yield: 65%) of white
solids of intermediate (B) were obtained.
B-benzo[b]naphtho[2,3-d]furan-2-yl-boronic acid 준비 용품 및 원자재
원자재
준비 용품
B-benzo[b]naphtho[2,3-d]furan-2-yl-boronic acid 공급 업체