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Terazosin hydrochloride

Terazosin hydrochloride 구조식 이미지
카스 번호:
63074-08-8
상품명:
Terazosin hydrochloride
동의어(영문):
Itrin;HYTRIN;Hitrin;Vicard;Dysalfa;Flotrin;Heitrin;Hytrine;Olyster;Teralfa
CBNumber:
CB9285510
분자식:
C19H26ClN5O4
포뮬러 무게:
423.89
MOL 파일:
63074-08-8.mol

Terazosin hydrochloride 속성

저장 조건
Store at RT
용해도
H2O: 25 mg/mL
물리적 상태
powder
색상
white to off-white
수용성
Soluble in water at 20mg/ml. Also soluble in methanol or ethanol.
CAS 데이터베이스
63074-08-8(CAS DataBase Reference)

안전

위험품 표기 Xn,Xi
위험 카페고리 넘버 22-36/37/38
안전지침서 26-36
WGK 독일 3
RTECS 번호 TK8044925

Terazosin hydrochloride C화학적 특성, 용도, 생산

개요

Terazosin hydrochloride is a highly water-soluble antihypertensive agent with a structure and profile closely related to that of prazosin.

Originator

Abbott (USA)

용도

Hytrin (Abbott).

상표명

Terazosin is INN and BAN;HEITRIN.

일반 설명

Terazosin hydrochloride, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine monohydrochloride (Hytrin), is a structuralcongener of prazosin hydrochloride. It possessessimilar selective properties of specifically inhibiting 1-adrenergic receptors. The drug is slightly less potent thanprazosin hydrochloride. Terazosin hydrochloride has a halflifeof approximately 12 hours, which is much longer thanthat of prazosin. This lends itself to a once-daily dose tocontrol hypertension in many patients.

생물학적 활성

α 1 - and α 2B -adrenoceptor antagonist (K i values are 3.3, 0.7, 1.1, 7.7, 1510 and 78.2 nM for α 1A , α 1B , α 1D , α 2B , α 2A and α 2C receptors respectively). Antihypertensive following oral or intravenous administration in vivo .

Terazosin hydrochloride 준비 용품 및 원자재

원자재

준비 용품


Terazosin hydrochloride 공급 업체

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