Quininib

Quininib 구조식 이미지
카스 번호:
143816-42-6
상품명:
Quininib
동의어(영문):
Quininib;Quininib >=98% (HPLC);(E)-2-(2-(quinolin-2-yl)vinyl)phenol;2-[(1E)-2-(2-quinolinyl)ethenyl]-phenol;Phenol, 2-[(1E)-2-(2-quinolinyl)ethenyl]-
CBNumber:
CB93152723
분자식:
C17H13NO
포뮬러 무게:
247.29
MOL 파일:
143816-42-6.mol

Quininib 속성

저장 조건
Store at -20°C
용해도
DMSO: 용해될 수 있다
물리적 상태
결정성 고체

안전

Quininib C화학적 특성, 용도, 생산

개요

Quininib is an antagonist of the cysteinyl leukotriene 1 (CysLT1) and CysLT2 receptors (IC50s = 1.4 and 52 μM, respectively). It inhibits tubule formation in HMEC-1 cells when used at concentrations of 3.16 and 10 μM and inhibits sprout formation in isolated mouse aortic rings in an ex vivo model of angiogenesis when used at 10 μM. Quininib (3 μM) decreases angiogenesis in an oxygen-induced retinopathy mouse model of ocular angiogenesis, preventing revascularization when used at concentrations of 0.5 and 3 μM, as well as increasing neovascularization and vascular density when used at 3 μM. It reduces tumor growth and inhibits angiogenesis in an HT-29 colorectal cancer mouse xenograft model when administered at a dose of 50 mg/kg every three days.

용도

Quininib is a novel regulator of Ocular Angiogenesis, significantly inhibiting angiogenic tubule formation in HMEC-1 cells, angiogenic sprouting in aortic ring explants and retinal revascularisation in OIR mice.

Quininib 준비 용품 및 원자재

원자재

준비 용품


Quininib 공급 업체

글로벌( 19)공급 업체
공급자 전화 이메일 국가 제품 수 이점
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32024 58
Guangzhou Isun Pharmaceutical Co., Ltd 020-39119399 18927568969
isunpharm@qq.com China 4428 55
ShangHai Angti Biotechnology Co., Ltd. 13764913901
info@angtibio.com China 4989 55
ATK CHEMICAL COMPANY LIMITED 3429815786 13301662590
sales@atkchemical.com China 9993 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
info@efebio.com China 9806 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774
sales@glpbio.cn China 6777 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767
sales@chemegen.com China 11217 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912
order@med-bio.cn China 8140 58
Energy Chemical 021-58432009 400-005-6266
marketing@energy-chemical.com China 44918 58
Changzhou Furuisi Biotechnology Co., Ltd 0519-85524369
3477467573@qq.com China 8617 58

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