1-Iodo-4-nitrobenzene

1-Iodo-4-nitrobenzene C화학적 특성, 용도, 생산

제조 방법

Preparation of 1-iodo-4-nitrobenzene from 4-Nitroaniline.
Principle: Diazonium salts undergo a large number of reactions in which the diazo group is lost as molecular nitrogen and is replaced by variety of other groups (e.g. OH, I, Br, Cl, F, CN, NO2, H, SO2H, Ar) which become attached to the aromatic ring.
Reaction:

Procedure: Take 0.5 g p-nitro aniline, 0.41 ml conc. H2SO4 and 3 ml water in a conical flask. Stir it well and cool to 0-5°C. Add a cold solution of 0.25 g NaNO2 in 0.75 ml distilled water to the above solution. Filter the resultant cold solution, and add the filtrate with stirring to a solution of 1 g KI in 3 ml water taken in a beaker. Filter the product separated out and wash it with water. Dry the product, record the practical yield and re-crystallize it.
Re-crystallization: Dissolve the crude product in minimum amount of ethyl alcohol in a beaker by heating on a water bath. Filter the hot solution and cool the filtrate. The shiny brown crystals of p-iodo nitro benzene separate out. Filter, dry and record the melting point and TLC (using toluene as a solvent).

Synthesis Reference(s)

Journal of the American Chemical Society, 83, p. 1928, 1961 DOI: 10.1021/ja01469a036
The Journal of Organic Chemistry, 33, p. 3670, 1968 DOI: 10.1021/jo01273a083

1-Iodo-4-nitrobenzene 준비 용품 및 원자재

원자재

준비 용품

1-Iodo-4-nitrobenzene 공급 업체

공급자	전화	이메일	국가	제품 수	이점
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
WinWin Chemical CO., Limited	+86-0577-64498589 +8615325081899	sales@win-winchemical.com	China	13854	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
Mainchem Co., Ltd.	+86-0592-6210733	sale@mainchem.com	China	32360	55
Beijing Ouhe Technology Co., Ltd	010-82967028 13552068683	2355560935@qq.com	China	12426	60
Chongqing Xingcan Pharmaceutical Technology Co., Ltd.	15523000485	xingcanyaoye@sina.com	China	1686	58
Shanghai Synchem Pharma Co., ltd	021-61984905-1 18016477331	synchempharma@aliyun.com	China	6454	55
Cool Pharm, Ltd	18019463053	sales@coolpharm.com	China	13017	58
Ningbo jinuo chemical co., LTD	0574-87314919 057487319282	info@nbinno.com	China	7216	58
Hubei Co-prosperity Medicine Technonlogy Co., Ltd	2383948258 19172820304	2383948258@qq.com	China	12994	58

1-Iodo-4-nitrobenzene 관련 검색: