Anti-Prion Protein antibody, Mouse monoclonal C화학적 특성, 용도, 생산
용도
Anti-Prion Protein antibody, mouse monoclonal may be used in:
immunoblotting
flow cytometry
immunocytochemistry
immunoprecipitation
immunoelectron microscopy
immunohistochemistry
enzyme linked immunosorbent assay
일반 설명
Anti-Prion Protein antibody, Mouse monoclonal (mouse IgG2b isotype) is derived from the hybridoma 8H4 produced by the fusion of mouse myeloma cells (SP2/0 cells) and splenocytes from Prnp-/- mice immunized with recombinant murine PrPc. Prion protein (PrP) is mapped to human chromosome 20p13. PrP is constitutively expressed in brain and other tissues of healthy humans and animals and is present in high levels at the synapse.
Biochem/physiol Actions
Prion-related diseases are fatal neurodegenerative disorders also known as transmissible spongiform encephalopathies (TSEs). Prion plaques are of three types: unicentric (single, compact core), multicentric (two or more cores and definite border), and diffuse plaques without a definite central core. Disease-associated prion protein specifically inhibits the proteolytic β-subunits of the 26S proteasome. This may clarify the mechanism of cell death by the prion protein. Prion protein may be involved in copper utilization, serving to buffer copper at the synaptic cleft or to mediate re-uptake of copper into the presynapse. Alternatively, bound copper may influence PrP binding characteristics. The PrP-copper complex may be crucial for synaptic homeostasis as a result of its antioxidant activity.
Anti-Prion Protein antibody, Mouse monoclonal 준비 용품 및 원자재
원자재
준비 용품
Anti-Prion Protein antibody, Mouse monoclonal 공급 업체
