아미솜트라딘
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아미솜트라딘 속성
- 녹는점
- 175°
- 끓는 점
- 331.89°C (rough estimate)
- 밀도
- 1.1985 (rough estimate)
- 굴절률
- 1.5100 (estimate)
- 저장 조건
- Amber Vial, -20°C Freezer, Under inert atmosphere
- 용해도
- DMSO(약간 용해됨), 메탄올(약간 용해됨)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 4.97±0.70(Predicted)
- 색상
- 흰색에서 옅은 베이지까지
- 안정성
- 감광성
안전
아미솜트라딘 C화학적 특성, 용도, 생산
Originator
Rolicton,Searle,US,1956Manufacturing Process
Preparation of the ethyl analog is as follows (methyl isocyanate is used in amisometradine manufacture).To a cooled and stirred solution of 142 parts of methallylamine in 900 parts of benzene, 156 parts of ethyl isocyanate are added dropwise. Upon concentration in vacuum N-ethyl-N'-methallylurea is obtained.
260 parts of this urea derivative are dissolved in 500 parts of acetic anhydride and treated with 157 parts of cyanoacetic acid at 60°C and heated at that temperature for 2 hours. The solution is then concentrated in vacuum to a syrup. 100 parts of water are added and the vacuum distillation is repeated. The remaining syrup contains a mixture of N-cyanoacetyl-N-ethyl-N'- methallylurea and a small quantity of N-cyanoacetyl-N-methallyl-N'-ethylurea.
This syrup is treated with sufficient 20% sodium hydroxide solution to raise the pH to 10. A violent reaction occurs. The reaction mixture is diluted with 50 parts of water, stirred, cooled and filtered. The material collected on the filter is recrystallized from 10% ethanol to yield a mixture of 1-methallyl-3-ethyl-6- amino-1,2,3,4-tetrahydro-2,4-pyrimidinedione and 1-ethyl-3-methallyl-6- amino-1,2,3,4-tetrahydro-2,4-pyrimidinedione melting at about 157-159°C.
Therapeutic Function
Diuretic아미솜트라딘 준비 용품 및 원자재
원자재
준비 용품
아미솜트라딘 공급 업체
글로벌( 9)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 |
1026@dideu.com | China | 8672 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 |
support@targetmol.com | United States | 19973 | 58 |
Energy Chemical | 021-58432009 400-005-6266 |
marketing@energy-chemical.com | China | 44941 | 58 |
Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 |
3477467573@qq.com | China | 8618 | 58 |
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd | 15229059051 |
1027@dideu.com | China | 9977 | 58 |
LGC Science (Shanghai) Ltd. | 17717235263 |
cindy.yang@lgcgroup.com | China | 11677 | 58 |