ABT 263 manufacturers and suppliers

ABT 263 suppliers

ABT 263

CAS:: 923564-51-6

MF:: C47H55ClF3N5O6S3

MW:: 974.61

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Properties

Melting point:: 114-116°C

Density: 1.41±0.1 g/cm3(Predicted)

storage temp.: -20°C Freezer, Under Inert Atmosphere

solubility: Soluble in DMSO (up to 25 mg/ml).

form: solid

pka: 4.60±0.10(Predicted)

color: White

Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Safety Information

HS Code: 29339900

Use

ABT-263 is structurally related to ABT-737; it is a disruptor of Bcl-2/Bcl-xL interactions with pro-apoptotic proteins. Overexpression of the prosurvival Bcl-2 family members is commonly associated with tumor maintenance, progression, and chemoresistance. [1] ABT-263 displays the protection afforded by overexpression of Bcl-2 or Bcl-xL with EC50 values of 60 nM and 20 nM, respectively. A wide range of cellular activity is observed with ABT-263 having a 50% growth inhibition (EC50) of 110 nM against the most sensitive line (H146), whereas its activity in the least sensitive line (H82) results in an EC50 at 22 M. All four cell lines with EC50 values of 400 nM (H146, H889, H1963, and H1417) are also highly sensitive to ABT-737, and the two most resistant lines (H1048 and H82) are similarly resistant to ABT-263.

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