BAY 11-7085 manufacturers and suppliers

BAY 11-7085 suppliers

Properties

Melting point:: 80-82℃

Boiling point:: 407.1±45.0 °C(Predicted)

Density: 1.144

Flash point:: 200℃

storage temp.: Sealed in dry,Room Temperature

solubility: DMSO: >25 mg/mL, soluble

form: solid

color: white

Sensitive: Light Sensitive

InChIKey: VHKZGNPOHPFPER-ONNFQVAWSA-N

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302-H315-H319-H335

Precautionary statements: P261-P280a-P304+P340-P305+P351+P338-P405-P501a

WGK Germany: 3

RTECS: UD1312500

HS Code: 29309090

Use

In the classical pathway of NF-κB activation, phosphorylation of the inhibitor of NF-κB (IκBα) releases the inhibitor from NF-κB, allowing IκBα degradation and NF-κB activation and nuclear import. BAY-11-7085 is an irreversible inhibitor of IκBα phosphorylation, preventing activation of NF-κB by cytokines and lipopolysaccharide (IC50 = 10 μM). It blocks gene expression that is regulated through the classical pathway of NF-κB activation and in this way blocks apoptosis, cell adhesion, and inflammation. BAY-11-7085 is also used to study IκBα actions that are independent of NF-κB signaling.

You can find BAY 11-7085 suppliers, manufacturers, and distributors from countries such as CHINA, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.