Bicalutamide manufacturers and suppliers

Bicalutamide suppliers

Properties

Melting point:: 191-193°C

Boiling point:: 650.3±55.0 °C(Predicted)

Density: 1.52±0.1 g/cm3(Predicted)

storage temp.: 2-8°C

solubility: DMSO: >5mg/mL

form: powder

pka: 11.49±0.29(Predicted)

color: White to Off-White

λmax: 270nm(CH3CN)(lit.)

Merck: 14,1200

Safety Information

Symbol(GHS): GHS08,GHS09

Signal word: Danger

Hazard statements: H351-H360FD-H410

Precautionary statements: P202-P273-P280-P308+P313-P391-P405

Hazard Codes: Xi

Risk Statements: 36/37/38

Safety Statements: 26-36-24/25

RIDADR: 3077

WGK Germany: 3

RTECS: TX1413500

HazardClass: 9

PackingGroup: III

HS Code: 29242995

Use

Bicalutamide was well tolerated in monotherapy as well as in combination. No dose-related increase in adverse events was reported. Adverse events were partially due to pharmacological effects of an anti-androgen, which include gynecomastia, breast tenderness, and hot flushes. Other non-pharmacological adverse events, with incidence equal or higher than 10% were, for example, constipation, nausea, diarrhea, asthenia, pain, and infection. The frequency of non-pharmacological adverse events was in the same range as reported for comparator in clinical trials. In contrast to flutamide, the incidence of diarrhea and liver abnormalities was much lower for bicalutamide. As compared with castration, monotherapy with bicalutamide allowed patients to maintain libido and have better physical capacity, thus resulting in better quality of life.Based on the results of the clinical trials mentioned above, bicalutamide was first approved in 1995. Bicalutamide is indicated for the use in combination with an LHRH-A analogue for metastatic prostate carcinoma (50mg).

You can find Bicalutamide suppliers, manufacturers, and distributors from countries such as China, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.