CO-1686 suppliers
CO-1686
- CAS:
- 1374640-70-6
- MF:
- C27H28F3N7O3
- MW:
- 555.55
Suppliers by country/region
Company Type
Properties
- Melting point:
- 202 - 205°C (dec.)
- Density
- 1.372±0.06 g/cm3(Predicted)
- storage temp.
- Amber Vial, -20°C Freezer, Under inert atmosphere
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 13.23±0.70(Predicted)
- color
- Off-White
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302-H315-H319-H335
- Precautionary statements
- P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501
- Risk Statements
- 23-25-36
- Safety Statements
- 24
- HS Code
- 29335990
Use
CO-1686 inhibited the p-EGFR in EGFR-expressing cells with an IC50 ranging from 62 to 187 nM while inhibiting EGFR phosphorylation. In three WT EGFR-expressing cells, the IC50 is larger than 2,000 nM. CO-1686 can selectively inhibit the growth of mutant EGFR expressing NSCLC cells with a GI50 ranging from 7 to 32 nM while inducing apoptosis. The CO-1686-resistant NSCLC cell line exhibited a signal for epithelial-mesenchymal transition and increased susceptibility to AKT inhibitors.
141 supplier list of "CO-1686"
- Product Name:Rociletinib
- Products Intro:Purity: NLT 98% | Package: 1G;1KG;100KG
- Company Type: Trader
- Country/Region: CHINA
- Main Products: 1159983-30-8,89466-59-1,149739-51-5,104901-79-3,10541-83-0
- Product Name:CO-1686
- Products Intro:Purity: 0.99 | Package: 5MG;10MG;50MG;100MG,1G,5G
- Company Type: Reagent
- Country/Region: CHINA
- Product Name:Rociletinib
- Products Intro:Package: 100mg | CustNote: BOC Sciences also provides custom synthesis services for Rociletinib.
- Company Type: Trader
- Country/Region: UNITED STATES
- Product Name:CO-1686
- Products Intro:Purity: 0.98 | Package: 1kg，2kg，5kg，10kg，25kg
- Company Type: Trader
- Country/Region: CHINA
- Main Products: 2,7-ADA,2,4,6-Trichloroaniline,TRIMETHYLOXONIUM TETRAFLUOROBORATE,Zinc sulfide,5-HEXEN-1-OL
- Product Name:rociletinib
- Products Intro:Purity: 0.99 | Package: 1kg; 25kg; or larger package as required | CustNote: pharmaceutical intermediates；Chemical Intermediate
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Specialty chemicals,OLED materials,Custom synthesis service
- Product Name:CO-1686
- Products Intro:Purity: 99.9% | Package: 25kgs/Drum;200kgs/Drum | CustNote: FDA GMP CEP Approved Manufacturer
- Company Type: Trader
- Country/Region: CHINA
![N-[3-[[2-[[4-(4-ACETYL-1-PIPERAZINYL)-2-METHOXYPHENYL]AMINO]-5-(TRIFLUOROMETHYL)-4-PYRIMIDINYL]AMINO]PHENYL]-2-PROPENAMIDE](https://img.chemicalbook.com/CompanyLogo/d89d97b5-e2b6-4934-ad8d-97ce609c517020210521134328.png)
- Product Name:N-[3-[[2-[[4-(4-ACETYL-1-PIPERAZINYL)-2-METHOXYPHENYL]AMINO]-5-(TRIFLUOROMETHYL)-4-PYRIMIDINYL]AMINO]PHENYL]-2-PROPENAMIDE
- Products Intro:Purity: 99% | Package: USP EP CP
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Pharmceutical,Optical Brightening,dyes
- Product Name:CO-1686
- Products Intro:Purity: 99% | Package: 5KG;1KG | CustNote: CO1686
- Company Type: Trader
- Country/Region: CHINA
- Main Products: sarms
- Product Name:CO-1686
- Products Intro:Purity: 97%+ | Package: 25g; 100g; 500g; 1kg; 25kg;bulk package
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Chemical reagent,Pharmaceutical intermediates,Catalyst
You can find CO-1686 suppliers,
manufacturers, and distributors from countries such as China, United States and the United Kingdom here.
Browse to the tetrahydrofuran product information displayed by the supplier,
as well as the supplier's contact and capability information.