Calicheamicin manufacturers and suppliers

Calicheamicin suppliers

Calicheamicin

CAS:: 108212-75-5

MF:: C55H74IN3O21S4

MW:: 1368.34

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Properties

alpha: D26 -124° (c = 0.98%, EtOH)

Density: 1.57±0.1 g/cm3(Predicted)

storage temp.: Store at -20°C

solubility: DMSO : ≥ 100 mg/mL (73.08 mM);Water : < 0.1 mg/mL (insoluble)

pka: 7.13±0.60(Predicted)

form: Solid

color: White to yellow

InChIKey: HXCHCVDVKSCDHU-PENQSKQENA-N

Safety Information

Symbol(GHS): GHS07,GHS08

Signal word: Danger

Hazard statements: H341-H372-H361-H302

Precautionary statements: P201-P202-P281-P308+P313-P405-P501-P264-P270-P301+P312-P330-P501-P260-P264-P270-P314-P501-P201-P202-P281-P308+P313-P405-P501

Use

Calicheamicin, also known as Calicheamicin gamma(1,I) or Calichemicin gamma1, is an potent enediyne antitumor antibiotics derived from the bacterium Micromonospora echinospora. Calicheamicin targets DNA and cause strand scission. Calicheamicin binds with DNA in the minor groove, wherein it then undergos a reaction analogous to the Bergman cyclization to generate a diradical species. This diradical, 1,4-didehydrobenzene, then abstracts hydrogen atoms from the deoxyribose (sugar) backbone of DNA, which ultimately leads to strand scission. The specificity of binding of calicheamicin to the minor groove of DNA is due to the aryltetrasaccharide group of the molecule.

You can find Calicheamicin suppliers, manufacturers, and distributors from countries such as China, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.