Carboplatin manufacturers and suppliers

Carboplatin suppliers

Properties

Melting point:: 228-230°C

storage temp.: 2-8°C

solubility: Sparingly soluble in water, very slightly soluble in acetone and in ethanol (96 per cent).

form: crystal

color: white

Water Solubility: Soluble in water.

Merck: 14,1822

Stability:: Stable. Incompatible with strong oxidizing agents.

InChI: InChI=1S/C6H8O4.2H3N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H3;/q;;;+2/p-2

InChIKey: OLESAACUTLOWQZ-UHFFFAOYSA-L

SMILES: C12(CCC1)C(=O)O[Pt]OC2=O.N.N

Safety Information

Symbol(GHS): GHS07,GHS08

Signal word: Danger

Hazard statements: H302+H312+H332-H317-H334-H340-H360

Precautionary statements: P201-P280-P301+P312-P302+P352+P312-P304+P340+P312-P308+P313

Hazard Codes: T

Risk Statements: 46-61-20/21/22-42/43-20/21

Safety Statements: 53-22-26-36/37/39-45

RIDADR: 2811

WGK Germany: 3

RTECS: TP2300000

HS Code: 28439000

Toxicity: LD50 in mice (mg/kg): 150 i.p., 140 i.v.; in rats (mg/kg): 85 i.v. (Lelieveld)

Use

Carboplatin, cis-diammine(1,1-cyclobutanedicarboxylato)platinum(II), is a second-generation platinum drug. Its structure is based on cisplatin with the difference that the chloride ligands are exchanged for a bidentate chelating ligand. A consequence is that carboplatin is less reactive than cisplatin and therefore is less nephrotoxic and orthotoxic than the parent compound. Unfortunately, it is more myelosuppressive than cisplatin, which reduces the patients’ white blood cell count and makes them susceptible to infections. Carboplatin was licensed by the FDA in 1989 under the brand name Paraplatin and has since then gained worldwide recognition. Carboplatin on its own or in combination with other anticancer agents is used in the treatment of a variety of cancer types including head and neck, ovarian, small-cell lung, testicular cancer and others. Carboplatin is a pale-white solid showing good aqueous solubility. The synthesis starts with potassium tetrachloroplatinate, which is reacted to the orange [PtI4]2- anion.

You can find Carboplatin suppliers, manufacturers, and distributors from countries such as China, India and the United States here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.