Oxaliplatin manufacturers and suppliers

Oxaliplatin suppliers

Properties

alpha: +74.5-78.0 (D/20)(c=0.5,H2O)

storage temp.: 2-8°C

solubility: Slightly soluble in water, very slightly soluble in methanol, practically insoluble in anhydrous ethanol.

form: solid

color: White to Almost white

Water Solubility: Soluble in water with heating and/or sonication

Merck: 14,6912

Stability:: Stable. Store cool. Incompatible with oxidizing agents.

InChI: InChI=1/C6H12N2.C2H2O4.Pt/c7-5-3-1-2-4-6(5)8;3-1(4)2(5)6;/h5-8H,1-4H2;(H,3,4)(H,5,6);/q-2;;+4/p-2/t5-,6-;;/s3

InChIKey: ZROHGHOFXNOHSO-BNTLRKBRSA-L

SMILES: O=C1C([O-][Pt+2]2(N[C@]3([H])CCCC[C@@]3([H])N2)[O-]1)=O |&1:6,12,r|

Safety Information

Symbol(GHS): GHS07,GHS08

Signal word: Danger

Hazard statements: H315-H317-H319-H335-H340-H360D

Precautionary statements: P202-P261-P280-P302+P352-P305+P351+P338-P308+P313

Hazard Codes: Xn,Xi

Risk Statements: 36/37/38-40-42/43

Safety Statements: 26-36

RIDADR: 2811

WGK Germany: 3

RTECS: TP2275850

HazardClass: 6.1(a)

PackingGroup: II

HS Code: 28439000

Toxicity: LD50 intraperitoneal in mouse: 19800ug/kg

Use

Oxaliplatin is a platinum-based antineoplastic agent that functions by forming DNA adducts specifically in cancer cells, preventing DNA replication and transcription which leads to cell death. Oxaliplatin has cytotoxic effects in a broad range of cell lines, including colon, ovarian, and lung cancer, with IC50 values ranging from 0.5-240, 0.12-19.8, and 2.6-6.1 μM, respectively. Through its general cytotoxic effects, oxaliplatin has anti-tumor activity against advanced colorectal cancer and is typically administered with fluorouracil and leucovorin in a combination known as FOLFOX.

You can find Oxaliplatin suppliers, manufacturers, and distributors from countries such as China, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.