Lorlatinib (PF-06463922) suppliers
Lorlatinib (PF-06463922)
- CAS:
- 1454846-35-5
- MF:
- C21H19FN6O2
- MW:
- 406.41
Suppliers by country/region
Company Type
Properties
- Melting point:
- 184-187°C
- Boiling point:
- 675.0±55.0 °C(Predicted)
- Density
- 1.42±0.1 g/cm3(Predicted)
- storage temp.
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly)
- form
- Solid
- pka
- 6.05±0.40(Predicted)
- color
- White to Off-White
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C21H19FN6O2/c1-11-15-7-13(22)4-5-14(15)21(29)27(2)10-16-19(17(8-23)28(3)26-16)12-6-18(30-11)20(24)25-9-12/h4-7,9,11H,10H2,1-3H3,(H2,24,25)/t11-/m1/s1
- InChIKey
- IIXWYSCJSQVBQM-LLVKDONJSA-N
- SMILES
- [C@@H]1(C)C2=CC(F)=CC=C2C(=O)N(C)CC2=NN(C)C(C#N)=C2C2C=C(C(N)=NC=2)O1
Safety Information
- Symbol(GHS)
GHS08
- Signal word
- Warning
- Hazard statements
- H341-H373
- Precautionary statements
- P260-P314-P501-P201-P202-P281-P308+P313-P405-P501
Use
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that promotes cell proliferation and blocks apoptosis. PF-06463922 is an ATP-competitive, selective inhibitor of ALK (Ki = < 0.07 nM) and c-Ros oncogene 1 (ROS1, Ki = 0.7 nM). It has strong activity against all known ALK and ROS1 mutants identified in patients, including the EML4-L1196M mutant of ALK (Ki = < 0.02 nM). PF-06463922 is orally available, displaying inhibition of ALK phosphorylation and antitumor efficacy in a xenograft model expressing EML4-L1196M ALK. It demonstrates efficient blood-brain barrier penetration, produces brain tumor regression in mice harboring EML4-ALK tumors, and increases overall survival.[Cayman Chemical]
202 supplier list of "Lorlatinib (PF-06463922)"
- Product Name:Lorlatinib (PF0643922)
- Products Intro:Purity: 0.98 | Package: 10mg, 10g, 50g, 100g, 1kg, 5kg, 10kg
- Company Type: Trader
- Country/Region: CHINA
- Main Products: OLED & OPV,APIs,Organic Chemicals,Peptides,BioChemicals
$8.00-1.00 / 1KG
- Product Name:Lorlatinib (PF-06463922)
- Products Intro:Purity: 99% | Package: 1KG;8USD|25KG;3USD|100KG;1USD
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Chemical raw materials,Organic raw materials,Petrochemicals,Chemical reagents,Intermediates
- Product Name:Pf-06463922
- Products Intro:Purity: 0.98 | Package: 100KG;10KG;5KG;1KG
- Company Type: Trader
- Country/Region: CHINA
- Main Products: 1159983-30-8,89466-59-1,149739-51-5,104901-79-3,10541-83-0
- Product Name:Lorlatinib (PF-06463922)
- Products Intro:Purity: 99% | Package: 25KG;5KG;1KG
- Company Type: Trader
- Country/Region: CHINA
- Product Name:Lorlatinib
- Products Intro:Purity: As coa | Package: As request | CustNote: 1454846-35-5
- Company Type: Trader
- Country/Region: CHINA
- Product Name:PF06463922
- Products Intro:Purity: 98% | Package: 10MG;50MG;100MG,1G,5G,10G.100G
- Company Type: Reagent
- Country/Region: CHINA
- Product Name:Lorlatinib
- Products Intro:Purity: >=98% | Package: 50mg | CustNote: BOC Sciences also provides custom synthesis services for Lorlatinib.
- Company Type: Trader
- Country/Region: UNITED STATES
- Product Name:PF-06463922
- Products Intro:Package: 1kg，2kg，5kg，10kg，25kg
- Company Type: Trader
- Country/Region: CHINA
- Main Products: 2,7-ADA,2,4,6-Trichloroaniline,TRIMETHYLOXONIUM TETRAFLUOROBORATE,Zinc sulfide,5-HEXEN-1-OL
$7.00/ 1KG
- Product Name:Lorlatinib
- Products Intro:Purity: 99% | Package: 1KG;7USD
- Company Type: Trader
- Country/Region: CHINA
- Product Name:Lorlatinib
- Products Intro:Purity: 98% | Package: 1g;USD|100g;USD|1KG;USD
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Phytic acid,Ortho Nitrobenzaldehyde,Phthalide,4-Cyanophenol,P-tert-Butyl Benzoic Acid(PTBBA)