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Temsirolimus

CAS:
162635-04-3
MF:
C56H87NO16
MW:
1030.29

Properties

Melting point:
99-101°C
Boiling point:
1048.4±75.0 °C(Predicted)
Density 
1.21
Flash point:
587.8℃
storage temp. 
-20°C Freezer
solubility 
Soluble in chloroform, methanol.
pka
10.40±0.70(Predicted)
form 
powder
color 
white to off-white
Merck 
14,9142
InChIKey
CBPNZQVSJQDFBE-FUXHJELOSA-N

Safety Information

Safety Statements 
24/25
WGK Germany 
3
RTECS 
VE6257000
HS Code 
29349990

Use

While renal cell carcinoma (RCC) accounts for only 2 3% of all cancers, the 5-year survival rate for advanced RCC disease is only 5 10%, with approximately 13,000 deaths occurring annually (US statistics only). Immunotherapeutic cytokine options, such as IFN-αand IL-2, have traditionally been frontline treatments, but these agents are not efficacious in all patients and can cause serious side effects. In addition, bevacizumab, a monoclonal antibody against VEGF, has also demonstrated prolongation of PFS. The newest entry for this indication focuses on targets that are downstream from VEGF. Temsirolimus is an inhibitor of the serine/threonine kinase mTOR, which is the mammalian target of rapamycin. mTOR has been implicated in cell replication through control of the cell cycle translation of specific mRNAs. Inhibition of mTOR prevents phosphorylation of the 4E binding protein-1 and the 40S ribosomal protein S6 kinase that are responsible for cell cycle protein translation initiation; cell cycle arrest occurs as the result of termination of cell division from the G1 to the S phase. Disruption of mTOR signaling also has antiangiogenic effects that could be deemed essential in combating RCC, which is driven by unregulated angiogenesis. Temsirolimus is the 2,2-bis(hydroxymethyl)propionate ester of rapamycin (sirolimus), a macrolide fungicide isolated from the bacteria Streptomyces hygroscopicus. Similar to its parent sirolimus, temsirolimus interacts with mTOR through its complex with FK-506 binding protein 12.

137 supplier list of "Temsirolimus"

  • Product Name:Temsirolimus
  • Products Intro:Purity: 0.99 | Package: 1KG,5KG,25KG | CustNote: Large package please cotact us
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: 13480692018
  • Product Name:Temsirolimus
  • Products Intro:Purity: 99% | Package: 100g,500g,1KG,10KG,100KG
  • Type of Enterprise: Reagent
  • Country/Region: CHINA
  • TEL: +86-371-55531817
  • Main Products: Speciality Chemicals
  • Product Name:Temsirolimus
  • Products Intro:Purity: 99% | Package: 500G;1KG;5KG;25KG
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: 0371-55170693
  • Product Name:Temsirolimus
  • Products Intro:Purity: 99% | Package: 100g;500g;1kg;25kg...
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: +86-21-33585366 E-mail:sales03@shyrchem.com
  • Product Name:Temsirolimus
  • Products Intro:Purity: 0.99 | Package: 5MG;10MG;50MG;100MG,1G,5G
  • Type of Enterprise: Reagent
  • Country/Region: CHINA
  • TEL: +86 21 5161 9050/ 5187 7795

    US $3.00/ 1KG

  • Product Name:Temsirolimus
  • Products Intro:Purity: 90%-99.9% | Package: 1KG;3USD
  • Type of Enterprise: Reagent
  • Country/Region: CHINA
  • TEL: +86-371-86658258
  • Main Products: Nicotinamide riboside chloride,Curcumin,L(+)-Ascorbic acid,L-Glutamine,Stevioside Basic information
  • Product Name:Temsirolimus
  • Products Intro:Purity: 98% HPLC LCMS | Package: 10G;20G
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: 0086-13720134139
  • Main Products: chemical products,reagents,kinase inhibitors,API
  • Product Name:Temsirolimus
  • Products Intro:Purity: 99% | Package: 5KG;1KG;25KG PRICE quotation | CustNote: Factory stock, quality assurance, price concessions
  • Type of Enterprise: Reagent
  • Country/Region: CHINA
  • TEL: 86-21-51086038
  • Product Name:Temsirolimus
  • Products Intro:Purity: 99% | Package: 5KG;1KG | CustNote: C56H87NO16
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: 86-18871470254
  • Main Products: Apis
  • Product Name:Temsirolimus
  • Type of Enterprise: Contractor
  • Country/Region: CHINA
  • TEL: 86-531-88032799
  • Main Products: Pharmaceutical Intermediates; Photoinitiator series

Temsirolimus Related Search:

D(+)-Pipecolinic acid1-methyl-piperidine-2-carboxylicacidmethylesterH-HOMOPRO-OME HCLEthyl 1-methylpipecolinate 2,2-Bis(hydroxymethyl)propionic acid2-(TETRAHYDRO-PYRAN-2-YL)-ETHYLAMINEEthyl pipecolinateTemsirolimusCHLOROPHOSPHONAZO IIIRapamycin3-(4-Hydroxyphenyl)propionic acid
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