Rapamycin manufacturers and suppliers

Rapamycin suppliers

Properties

Melting point:: 183-185°C

alpha: D25 -58.2° (methanol)

Boiling point:: 799.83°C (rough estimate)

Density: 1.0352 (rough estimate)

vapor pressure: 0.56 hPa ( 20 °C)

refractive index: 1.5280 (estimate)

Flash point:: 87 °C

storage temp.: -20°C

solubility: ethanol: soluble2MM

pka: 10.40±0.70(Predicted)

form: solution

color: colorless to yellow

Water Solubility: Soluble in DMSO at 50mg/ml or methanol at 25mg/mlSoluble in alcohol, dimethyl sulfoxide and dimethyl formamide. Insoluble in water.

Sensitive: Moisture Sensitive/Light Sensitive/Hygroscopic

Merck: 14,8114

Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.

InChIKey: QFJCIRLUMZQUOT-HPLJOQBZSA-N

CAS DataBase Reference: 53123-88-9(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS08

Signal word: Warning

Hazard statements: H351-H361fd

Precautionary statements: P201-P202-P280-P308+P313-P405-P501

PPE: Eyeshields, Gloves, type N95 (US)

Hazard Codes: Xi,Xn,F

Risk Statements: 36/38-36-20/21/22-11

Safety Statements: 22-24/25-37/39-26-36/37-16

RIDADR: UN 1648 3 / PGII

WGK Germany: 2

RTECS: VE6250000

Autoignition Temperature: 301 °C

HS Code: 29349990

Storage Class: 11 - Combustible Solids

Hazard Classifications: Carc. 2
Repr. 2

Hazardous Substances Data: 53123-88-9(Hazardous Substances Data)

Toxicity: LD50 in mice (mg/kg): 600 i.p.; >2,500 orally (Vézina)

REACH Registrations: Active

Use

Rapamycin is a triene macrolide discovered in 1974 as a metabolite of Streptomyces hygroscopicus found in a soil obtained on Rapa Nui (Easter Island). Rapamycin displayed potent and selective antifungal activity, notably against Candida albicans. Interest in the metabolite waned until the structural relationship to the potent immunosuppressant fujimycin (Antibiotic FK506) was recognised in the mid-1980s. This recognition led to the re-discovery of rapamycin as a highly selective antitumor and immunosuppressant. Rapamycin inhibits the activity of the protein, mTOR (mammalian target of rapamycin) which functions in a signalling pathway to promote tumor growth. Rapamycin binds to a receptor protein (FKBP12). The rapamycin/FKB12 complex then binds to mTOR and prevents interaction of mTOR with target proteins in this signalling pathway.

You can find Rapamycin suppliers, manufacturers, and distributors from countries such as China, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.