Amifostine manufacturers and suppliers

Amifostine suppliers

Properties

Melting point:: 160-1610C

Boiling point:: 441.7±51.0 °C(Predicted)

Density: 1.367±0.06 g/cm3(Predicted)

storage temp.: 2-8°C

solubility: Soluble in Water.

form: powder

pka: 1.28±0.10(Predicted)

color: White

Water Solubility: Soluble to 100 mM in water

Stability:: Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302

Precautionary statements: P264-P270-P301+P312-P330-P501

Hazard Codes: Xn,Xi

Risk Statements: 22-36/37/38

Safety Statements: 26-36

WGK Germany: 3

RTECS: TE6491000

Toxicity: cyt-mus-ipr 300 mg/kg CUSCAM 54,1080,85

Use

Amifostine, an organic thiophosphate, was introduced for the reduction of cisplatin-induced renal toxicity in patients with advanced ovarian cancer. It is also a radio-protective agent. Amifostine is a prodrug which is rapidly dephosphorylated, preferentially in non-tumor tissues to the active thiol. This agent binds to chemotherapeutic drugs and free radicals released by radiotherapy. The protective effect of amifostine was observed in a wide range of normal organs including bone marrow and gastrointestinal mucosa without interfering with the anti-tumor effect of chemohadiotherapy, indicating an increased therapeutic index for existing cancer treatment. Amifostine is also being evaluated as a cytoprotective in other types of tumors including lung, breast, head and neck cancers. It was reported to be a potent mucolytic with potential in cystic fibrosis.

You can find Amifostine suppliers, manufacturers, and distributors from countries such as China, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.