Atosiban manufacturers and suppliers

Atosiban suppliers

Properties

Melting point:: >165oC (dec.)

Boiling point:: 1469.0±65.0 °C(Predicted)

Density: 1.254±0.06 g/cm3(Predicted)

storage temp.: -20°C

solubility: H₂O: ≤100 mg/mL

form: solid

pka: 12.81±0.70(Predicted)

color: White to Off-White

Water Solubility: Soluble to 50 mg/ml in water

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H315-H319-H335

Precautionary statements: P271-P261-P280

WGK Germany: 3

RTECS: RS7590000

HS Code: 2934999090

Use

Atosiban was introduced in the UK as an injectable inhibitor of preterm labor, a major cause of infant morbidity and mortality. This peptidic oxytocin analog is an antagonist of the vasopressin V1a receptor and of the oxytocin receptor which is found in dramatically increased concentration in the uterine myometrium of pregnant women near term. It competitively inhibited contractions in the pregnant guinea pig uterus induced by oxytocin and vasopressin. In a multicenter, double-blind, placebo-controlled trial, treatment with atosiban caused pregnancy prolongation for up to 7 days in women with more than 28 weeks of gestation. In a comparative clinical trial, atosiban showed a comparable tocolytic action (uterine relaxant) to ritodrine but the former was significantly better tolerated, especially with regards to maternal cardiovascular side effects. In healthy volunteers, plasma levels of atosiban decreased bi-exponentially with an initial and a terminal half-life of 21 min and 1.7h respectively.

You can find Atosiban suppliers, manufacturers, and distributors from countries such as China, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.