Cilastatin sodium manufacturers and suppliers

Cilastatin sodium suppliers

Properties

Melting point:: >160°C (dec.)

Flash point:: 87℃

storage temp.: 2-8°C

solubility: Very soluble in water and in methanol, slightly soluble in anhydrous ethanol, very slightly soluble in dimethyl sulfoxide, practically insoluble in acetone and in methylene chloride.

form: Solid

pka: pKa1 2.0; pKa2 4.4; pKa3 9.2(at 25℃)

color: White

biological source: synthetic (organic)

Water Solubility: water: 10mg/mL, clear, colorless to faintly yellow

Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

InChIKey: QXPBTTUOVWMPJN-LZTDVXLXNA-M

SMILES: [C@H]1(C(=O)N/C(=C\CCCCSC[C@H](N)C(O)=O)/C(=O)[O-])CC1(C)C.[Na+] |&1:0,12,r|

CAS DataBase Reference: 81129-83-1(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H319

Precautionary statements: P264-P280-P305+P351+P338-P337+P313P

RTECS: MJ9650200

HS Code: 2941.90.1050

Use

ChEBI: The monosodium salt of cilastatin. It is an inhibitor of dehydropeptidase I (membrane dipeptidase, 3.4.13.19), an enzyme found in the brush border of renal tubes and responsible for degrading the antibiotic imipenem. Cilastatin sodium is therefore administ red with imipenem to prolong the antibacterial effect of the latter by preventing its renal metabolism to microbiologically inactive and potentially nephrotoxic products.

You can find Cilastatin sodium suppliers, manufacturers, and distributors from countries such as China, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.