Ciprofibrate manufacturers and suppliers

Ciprofibrate suppliers

Properties

Melting point:: 114-116°

Boiling point:: 401.74°C (rough estimate)

Density: 1.2576 (rough estimate)

refractive index: 1.5209 (estimate)

storage temp.: 2-8°C

solubility: Practically insoluble in water, freely soluble in anhydrous ethanol, soluble in toluene.

pka: 3.31±0.10(Predicted)

form: Solid

color: White to Pale Beige

Merck: 14,2313

InChI: InChI=1S/C13H14Cl2O3/c1-12(2,11(16)17)18-9-5-3-8(4-6-9)10-7-13(10,14)15/h3-6,10H,7H2,1-2H3,(H,16,17)

InChIKey: KPSRODZRAIWAKH-UHFFFAOYSA-N

SMILES: C(O)(=O)C(OC1=CC=C(C2CC2(Cl)Cl)C=C1)(C)C

CAS DataBase Reference: 52214-84-3(CAS DataBase Reference)

EPA Substance Registry System: Propanoic acid, 2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methyl- (52214-84-3)

Safety Information

Symbol(GHS): GHS08

Signal word: Danger

Hazard statements: H350

Precautionary statements: P201-P308+P313

Hazard Codes: T

Risk Statements: 45

Safety Statements: 53-22-36/37/39-45

WGK Germany: 3

RTECS: UF0880000

HS Code: 29189900

Use

Peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription factor involved in the regulation of lipid homeostasis. Activation of PPARα results in expression of a variety of genes, particularly those involved in fatty acid β-oxidation, binding, and transport. Ciprofibrate activates PPARα with an EC50 value of 20 μM and only marginally affects PPARγ (EC50 = >300 μM). It has been shown to lower adipose tissue weight and reduce plasma insulin concentrations in obese rats and has been used clinically in the treatment of dyslipidemia. Ciprofibrate reportedly stimulates cholesteryl ester transfer protein expression and improves the flow of cholesterol through the indirect reverse cholesterol transport system, preserving plasma HDL.

You can find Ciprofibrate suppliers, manufacturers, and distributors from countries such as China, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.