Deoxyribonuclease manufacturers and suppliers

Deoxyribonuclease suppliers

Properties

Density: 100 g/mL at 20 °C

vapor pressure: 0.004Pa at 25℃

storage temp.: -20°C

solubility: Soluble in 0.15 M sodium chloride (5.0mg/L) clear.

form: solution (clear, colorless)

color: white

biological source: bovine pancreas

Water Solubility: 125g/L at 25℃

Merck: 13,2923

Specific Activity: 1700—2300U/vial

LogP: -1.3 at 20℃

EPA Substance Registry System: Nuclease, deoxyribo- (9003-98-9)

Safety Information

Symbol(GHS): GHS08

Signal word: Danger

Hazard statements: H334

Precautionary statements: P261-P284-P501

Safety Statements: 23-24/25-22

WGK Germany: 3

RTECS: RF0750000

F: 10-21

TSCA: Yes

HS Code: 35079090

Use

DNAse is a human endonuclease, normally present insaliva, urine, pancreatic secretions, and blood. Aerosolized recombinant human deoxyribonucleaseI (rhDNAse), dornase alfa, Pulmozyme, has beenformulated into an inhalation agent for the treatment of pulmonarydisease in patients with CF.Among the clinical manifestations of CF are obstructionof the airways by viscous, dehydrated mucus. Pulmonaryfunction is diminished, and microbes can become entrappedin the viscid matrix. A cycle of pulmonary obstruction andinfection leads to progressive lung destruction and eventualdeath before the age of 30 for most CF patients. The immunesystem responds by sending in neutrophils, and theseaccumulate and eventually degenerate, releasing largeamounts of DNA. The high levels of extracellular DNA releasedand the mucous glycoproteins are responsible for thedegenerating lung function. The DNA-rich secretions alsobind to aminoglycoside antibiotics typically used to treat theinfections. In vitro studies showed that the viscosity of thesecretions could be reduced by application of DNAse I.

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