Fluphenazine-N-2-chloroethane (hydrochloride) manufacturers and suppliers

Fluphenazine-N-2-chloroethane (hydrochloride) suppliers

Fluphenazine-N-2-chloroethane (hydrochloride)

CAS:: 3892-78-2

MF:: C22H26Cl2F3N3S

MW:: 492.4281496

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Properties

Melting point:: 224-225 °C

storage temp.: Store at -20°C

solubility: DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 1 mg/ml

form: A crystalline solid

color: White to off-white

Safety Information

Use

Fluphenazine is a traditional antipsychotic compound that tightly binds the dopamine D2 receptor (Ki = 0.55 nM) and also reversibly inhibits calmodulin at micromolar concentrations. Fluphenazine-N-2-chloroethane (hydrochloride) is a derivative of fluphenazine that contains an alkylating chlorethylamine chain, which produces irreversible protein binding. It is a relatively selective, irreversible antagonist of D2 receptors both in vitro (IC50 = 100 nM) and in vivo, inactivating approximately 90% of D2 receptors in mice within 4 hours of treatment. Through this action, fluphenazine-B-2-chloroethane can be used to induce catalepsy in mice. It irreversibly inhibits calmodulin at higher doses (IC50 = 10 μM), which can sensitize cancer cells to TRAIL-induced apoptosis.[Cayman Chemical]

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