HIRUDIN suppliers
HIRUDIN
- CAS:
- 8001-27-2
- MF:
- C287H440N80O113S7
- MW:
- 7043.4877
Suppliers by country/region
Company Type
Properties
- storage temp.
- 2-8°C
- form
- lyophilized powder
- color
- white
- Merck
- 13,4737
Safety Information
- Symbol(GHS)
GHS07,GHS08
- Signal word
- Danger
- Hazard statements
- H317-H334
- Precautionary statements
- P280
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- RTECS
- MR8440000
- F
- 10-21
- HS Code
- 3504009000
Use
Refludan was launched in Germany for heparin-associated thrombocytopenia. Originally isolated from the saliva of leeches (Hirudo medicinalis), the gene for recombinant hirudin was synthesized and expressed in Saccharomyces cerevisiae. The isolated protein is 65 amino acids differing from the native protein by the first two amino acids (Leu1 and Thr2) and Tyr63 is not sulfated, while it does retain the three disulfide bonds. Refludan is a potent, specific and almost irreversible inhibitor of thrombin with which it forms a 1:1 complex. The N-terminal domain binds to the active catalytic site of thrombin, while the C-terminal end binds to the anion binding exosite (fibrinogen binding cleft). It has several advantages over heparin: it can inhibit thrombin bound to extracellular matrices, does not require antithrombin Ⅲ as a cofactor, is not inhibited by activated platelet nor increases platelet activity, and is a pure, single compound with a single mechanism of action. It is useful for myocardial infarcts, unstable angia and cardiovascular events. Heparin treatment can be inhibited by platelets activated by the Fc fragment of antibodies developed to the antigen of heparin-platelet factor 4. A corresponding inactivation of Refuldan is not known.
71 supplier list of "HIRUDIN"
$7.00/ 1KG
- Product Name:HIRUDIN
- Products Intro:Purity: 99% | Package: 1KG;7USD
- Company Type: Trader
- Country/Region: CHINA
- Product Name:Hirudin
- Products Intro:Purity: 0.99 | Package: 25kg,50kg,180kg,200kg,250kg,1000kg,as your needs | CustNote: as your needs
- Company Type: Trader
- Country/Region: CHINA
- Product Name:Hirudin
- Products Intro:Purity: 99% | Package: 5kg;1KG;0.5KG; 0.1KG;,0.01KG/BAG
- Company Type: Trader
- Country/Region: CHINA
- Main Products: VK2 MK7 0.2%~2%,S-Adenosyl-L-methionine Disulfate Tosylate (SAME),Citicoline CAS 987-78-0,PQQ(Pyrroloquinoline Quinone Disodium Salt),D-chiro-inositol
- Product Name:Hirudinrecombinantfromyeast
- Products Intro:Brand:sigma aldrich | Product Number:94581 | Purity:lyophilizedpowder,white,>1500?U/vial
- Company Type: Trader
- Country/Region: INDIA