METHAPYRILENE manufacturers and suppliers

METHAPYRILENE suppliers

METHAPYRILENE

CAS:: 91-80-5

MF:: C14H19N3S

MW:: 261.38576

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Properties

Melting point:: 25°C

Boiling point:: bp0.45 125-135°; bp3 173-175°

Density: 1.1388 (rough estimate)

refractive index: nD25 1.5842 (also reported as 1.5835)

storage temp.: Refrigerator, under inert atmosphere

solubility: DMSO (Sparingly), Methanol (Slightly)

form: Oil

pka: pKa 3.02 ± 0.05;8.24± 0.11(H2O,t undefined,I=0.30(NaCl)) (Uncertain)

color: Colourless to Light Yellow

Water Solubility: 601.2mg/L(30 ºC)

Stability:: Stable. Incompatible with strong oxidizing agents.

Safety Information

Symbol(GHS): GHS06

Signal word: Danger

Hazard statements: H301

Precautionary statements: P264-P270-P301+P310-P321-P330-P405-P501

RIDADR: 1851

HazardClass: 6.1(b)

PackingGroup: III

Toxicity: LD50 in mice, guinea pigs (mg/kg): 182.2 ±12.8, 374.9 ±34.5 orally; in mice (mg/kg): 19.85 ±0.69 i.v. (Lee)

Use

Methapyrilene, an antihistamine with moderate sedative activity, was introduced in 1947 for the treatment of various allergic conditions and was subsequently incorporated in many over-the-counter sleeping aids. In the early 1970s it was identified as a carcinogen in rats and, although there was no direct evidence that it constitutes a health hazard to man, it was withdrawn in many countries. (Reference: (WHODI) WHO Drug Information, 2, 4, 1979)

You can find METHAPYRILENE suppliers, manufacturers, and distributors from countries such as United States, China here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.