Nalmefene manufacturers and suppliers

Nalmefene suppliers

Properties

Melting point:: 182-185C

Boiling point:: 507.9±50.0 °C(Predicted)

Density: 1.38±0.1 g/cm3(Predicted)

storage temp.: 2-8°C

solubility: Chloroform (Slightly), Dichloromethane (Slightly), DMSO (Slightly)

pka: pKa 7.63(H2O) (Uncertain)

form: Solid

color: White to Off-White

Henry's Law Constant: 5.5×10¹⁰ mol/(m³Pa) at 25℃, HSDB (2015)

InChI: 1S/C21H25NO3/c1-12-6-7-21(24)16-10-14-4-5-15(23)18-17(14)20(21,19(12)25-18)8-9-22(16)11-13-2-3-13/h4-5,13,16,19,23-24H,1-3,6-11H2/t16-,19+,20+,21-/m1/s1

InChIKey: WJBLNOPPDWQMCH-MBPVOVBZSA-N

SMILES: Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=C)CC[C@@]35O)CC6CC6

CAS DataBase Reference: 55096-26-9

NIST Chemistry Reference: Nalmefene(55096-26-9)

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H315-H319-H335

Precautionary statements: P261-P305+P351+P338

target organs: Central nervous system

PPE: dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes: Xi

Risk Statements: 36/37/38

Safety Statements: 26-36

WGK Germany: 3

Storage Class: 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications: Acute Tox. 3 Oral
Aquatic Chronic 1
STOT SE 3

Hazardous Substances Data: 55096-26-9(Hazardous Substances Data)

Use

Nalmefene (Revex) is a pure opioid antagonist that is the6-methylene analog of naltrexone. It is available as a solutionfor IV, IM, or subcutaneous (SC) administration toreverse the effects of opioids after general anesthesia andin the treatment of overdose. It is longer acting than naloxonebut otherwise has a similar pharmacodynamic andmetabolic (3-glucuronidation) profile. Nalmefene hashigher oral bioavailability (approximately 40%) thannaloxone or naltrexone and is currently being investigatedas an oral treatment for pathological gambling and alcoholabuse.

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