nifurtimox suppliers
nifurtimox
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Properties
- Melting point:
- 177-183°C
- Boiling point:
- 550.3±50.0 °C(Predicted)
- Density
- 1.4716 (rough estimate)
- refractive index
- 1.6390 (estimate)
- storage temp.
- room temp
- solubility
- DMSO: ≥13mg/mL
- pka
- -1.01±0.40(Predicted)
- form
- powder
- color
- yellow to orange
- Water Solubility
- 33g/L(temperature not stated)
- BCS Class
- 3
- InChIKey
- ARFHIAQFJWUCFH-IZZDOVSWSA-N
Safety Information
- Symbol(GHS)
GHS08
- Signal word
- Warning
- Hazard statements
- H373
- Precautionary statements
- P260-P314-P501
- WGK Germany
- 3
- Toxicity
- LD50 in mice, rats (mg/kg): 3720, 4050 by gavage (Hoffmann)
Use
Nifurtimox is 4-[(5-nitrofurfurylidene) amino]-3-methylthiomorpholine-1,1-dioxide, or Bayer 2502 (Lampit). Theobservation that various derivatives of 5-nitrofuraldehydepossessed, in addition to their antibacterial and antifungal properties, significant and potentially useful antiprotozoalactivity eventually led to discovery of particular nitrofuranswith antitrypanosomal activity.The most important of such compounds is nifurtimox becauseof its demonstrated effectiveness against T. cruzi, theparasite responsible for South American trypanosomiasis. Infact, use of this drug represents the only clinically proventreatment for both acute and chronic forms of the disease.Nifurtimox is available in the United States from the CDC.Nifurtimox is administered orally. Oral bioavailability ishigh, but considerable first-pass metabolism occurs. Thehalf-life of nifurtimox is 2 to 4 hours. The drug is poorly tolerated,with a high incidence of nausea, vomiting, abdominalpain, and anorexia reported. Symptoms of central andperipheral nervous system toxicity also frequently occurwith nifurtimox.
55 supplier list of "nifurtimox "
- Product Name:nifurtimox
- Products Intro:Purity: 0.99summer | Package: 5KG;1KG | CustNote: Summer 618
- Company Type: Trader
- Country/Region: CHINA
- Product Name:nifurtimox
- Products Intro:Purity: 99.9% | Package: 25kgs/Drum;200kgs/Drum | CustNote: FDA GMP CEP Approved Manufacturer
- Company Type: Trader
- Country/Region: CHINA
- Product Name:NIFURTIMOX
- Products Intro:Purity: 99% | Package: USP EP CP
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Pharmceutical,Optical Brightening,dyes
- Product Name:Nifurtimox
- Products Intro:Purity: 98% | Package: 1g,10g,25g,500g,1kg
- Company Type: Trader
- Country/Region: CHINA
- Main Products: 528-94-9,AMMONIUM SALICYLATE,Linolenic acid,463-40-1,931-36-2
- Product Name:Nifurtimox
- Company Type: Reagent
- Country/Region: UNITED STATES
- Main Products: Active Pharmaceutical Ingredient (API),Insect Pheromone,Boronic Compounds,Material & Chemicals,Lipid Compounds
- Product Name:nifurtimox
- Products Intro:Package: 1g; 5g; 25g; 1kg; 5kg; 25kg
- Company Type: Trader
- Country/Region: CHINA
- Main Products: pharmaceuticals,intermediates,fine chemicals,screening compounds,building blocks
- Product Name:nifurtimox
- Products Intro:Purity: 98%+ | Package: 500mg;1g;500g；1kg | CustNote: Topule Company operates with integrity and has its own laboratory, which supports packaging and customization. Payment will be made after the product has passed third-party testing
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Pharmaceutical intermediates,raw materials,small molecule inhibitors,food additives,Biochemical reagents
- Product Name:Nifurtimox
- Products Intro:Purity: 99% | Package: 50mg, 100mg, 5mg, 10mg
- Company Type: Trader
- Country/Region: CHINA
- Product Name:Nifurtimox
- Products Intro:Purity: 98% | Package: $117.9/5mg;$531.9/25mg;$721.9/50mg;$1137.9/100mg;Bulk package | CustNote: 98%
- Company Type: Trader
- Country/Region: UNITED STATES
- Main Products: Chemicals and BioChemicals,Materials Science,ligands acting on targets,Proteins,Antibodies
- Product Name:Nifurtimox
- Products Intro:Purity: 0.97 | Package: mgs,gs,kgs | CustNote: A912676
- Company Type: Reagent
- Country/Region: CHINA