Nimesulide manufacturers and suppliers

Nimesulide suppliers

Properties

Melting point:: 140-146°C

Boiling point:: 442.0±55.0 °C(Predicted)

Density: 1.451±0.06 g/cm3(Predicted)

storage temp.: 2-8°C

solubility: Practically insoluble in water, freely soluble in acetone, slightly soluble in anhydrous ethanol.

form: Solid

pka: pKa 6.56± 0.03(H2O,t =25,I=0.02)(Approximate)

color: Light orange to Yellow to Green

biological source: synthetic (organic)

Water Solubility: Soluble in water (<50 µg/ml), 1:10 DMSO:PBS (pH 7.2) (<200 µg/ml), ethanol (1 mg/ml), DMSO (15 mg/ml), DMF (15 mg/ml), chloroform, dichloromethane, acetone (freely soluble), and 1N NaOH.

λmax: 391nm(H2O)(lit.)

Merck: 14,6548

Stability:: Stable. Incompatible with strong oxidizing agents.

Major Application: pharmaceutical (small molecule)

InChI: 1S/C13H12N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h2-9,14H,1H3

InChIKey: HYWYRSMBCFDLJT-UHFFFAOYSA-N

SMILES: CS(NC1=C(OC2=CC=CC=C2)C=C([N+]([O-])=O)C=C1)(=O)=O

CAS DataBase Reference: 51803-78-2(CAS DataBase Reference)

EPA Substance Registry System: Methanesulfonamide, N-(4-nitro-2-phenoxyphenyl)- (51803-78-2)

Safety Information

Symbol(GHS): GHS06

Signal word: Danger

Hazard statements: H301

Precautionary statements: P301+P310+P330

Hazard Codes: Xn,Xi

Risk Statements: 22-36/37/38

Safety Statements: 36-26

RIDADR: UN 2811 6.1/PG 3

WGK Germany: 3

RTECS: PB0970000

HS Code: 2935.90.9500

HazardClass: 6.1

PackingGroup: III

Storage Class: 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications: Acute Tox. 3 Oral

Toxicity: LD50 orally in rats: 324 mg/kg (Swingle, Moore)

Limited Quantities: 5.0 kg (11 lbs) (solid)

Excepted Quantities: Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

Use

Labelled Nimesulide . Antiinflammatory agent. Preferentially inhibits COX-2 over COX-1. Suppresses chemical-induced carcinogenesis in mice and rats. Inhibits LPS-induced TNF-α production.;Labeled Nimesulide, intended for use as an internal standard for th

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