Norepinephrine manufacturers and suppliers

Norepinephrine suppliers

Properties

Melting point:: 220-230°C

alpha: D25 -37.3° (c = 5 in water with 1 equiv HCl)

Boiling point:: 298.46°C (rough estimate)

Density: 1.2435 (rough estimate)

refractive index: 1.5100 (estimate)

storage temp.: 2-8°C

solubility: Aqueous Acid (Slightly), DMSO (Slightly)

form: crystalline

pka: 8.64(at 25℃)

color: off-white to tan

Water Solubility: Soluble in alkali and dilute hydrochloric acid. Slightly soluble in water, ethanol and diethyl ether.

Sensitive: Air & Light Sensitive

Merck: 14,6695

BRN: 4231961

Stability:: Stable, but may be light-sensitive. Incompatible with acids, bases, oxidizing agents. Store at -20℃.

Safety Information

Symbol(GHS): GHS06

Signal word: Danger

Hazard statements: H300+H310+H330

Precautionary statements: P260-P262-P264-P280-P302+P352+P310-P304+P340+P310

Hazard Codes: T+,C,F

Risk Statements: 26/27/28-34-11-28

Safety Statements: 28-36/37-45-36/37/39-26-16-20

RIDADR: UN 2811 6.1/PG 2

WGK Germany: 3

RTECS: DN5950000

F: 8-10-23

HazardClass: 6.1

PackingGroup: II

HS Code: 29225090

Toxicity: dni-hmn:oth 5800 nmol/L CNREA8 40,1414,80

Use

Norepinephrine (NE, Levophed) differs from DA onlyby addition of a 1-OH substituent (β-OH-DA) and from Eonly by lacking the N-methyl group. Like DA, it is polar andrapidly metabolized by both COMT and MAO, resulting inpoor oral bioavailability and short DOA (1 or 2 minutes evenwhen given intravenously). It is a stimulant of α1-, α2-, andβ1-adrenoceptors (notice that lacking the N-methyl group resultsin lacking β2- and β3-activity). It is used to counteractvarious hypotensive crises, because its α-activity raisesblood pressure and as an adjunct treatment in cardiac arrestbecause its β-activity stimulates the heart. It has limitedclinical application caused by the nonselective nature of itsactivities.

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