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Indications and Usage Mechanisms of Action Adverse Effects
Oxaliplatin structure
Chemical Name:
Molecular Formula:
Formula Weight:
MOL File:

Oxaliplatin Properties

+74.5-78.0 (D/20)(c=0.5,H2O)
storage temp. 
Store at +4°C
Slightly soluble in water, very slightly soluble in methanol, practically insoluble in anhydrous ethanol.
Water Solubility 
Soluble in water with heating and/or sonication
Stable. Store cool. Incompatible with oxidizing agents.
CAS DataBase Reference
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,Xi
Risk Statements  36/37/38-40-42/43
Safety Statements  26-36
RIDADR  2811
WGK Germany  3
RTECS  TP2275850
HazardClass  6.1(a)
PackingGroup  II
HS Code  28439000
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled Sensitisation, respiratory Category 1 Danger P261, P285, P304+P341, P342+P311,P501
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P284 Wear respiratory protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Oxaliplatin price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich O9512 Oxaliplatin solid 61825-94-3 5mg $97.8 2018-11-13 Buy
Sigma-Aldrich 1481204 Oxaliplatin United States Pharmacopeia (USP) Reference Standard 61825-94-3 125mg $1808.1 2018-11-13 Buy
TCI Chemical O0372 Oxaliplatin 61825-94-3 100mg $159 2018-11-22 Buy
Alfa Aesar J66586 Oxaliplatin 61825-94-3 50mg $146 2018-11-13 Buy
Cayman Chemical 13106 Oxaliplatin ≥98% 61825-94-3 50mg $62 2018-11-13 Buy

Oxaliplatin Chemical Properties,Uses,Production

Indications and Usage

Oxaliplatin, also called Eloxatin or Eloxatine, is a platinum derivative.
Used clinically to treat patients with metastatic colorectal cancer after failure of fluorouracil treatment, can be used alone or in combination with 5-fluorouracil. It is the third-generation platinum antitumor compound after cisplatin and carboplatin, and so far the only platinum-based drug with significant effectiveness against colorectal cancer. It also inhibits proliferation of ovarian cancer and melanoma cell lines.

Mechanisms of Action

Acts on DNA through production of alkylating conjugates, inhibiting its synthesis and reproduction by forming interchain and intrachain cross-links.

Adverse Effects


Eloxatin was launched in France for second-line treatment of metastatic colorectal cancer. Oxaliplatin is a second generation platinum drug prepared in three steps from either k2tCl4 or K2Ptl4. It has an antitumor spectrum similar to cisplatin, however, it is more effective against L1210 leukemia and cisplatin resistant L1210. It is also effective against B16 melanoma but has a dose limiting toxicity of peripheral sensory neuropathy that is reversible upon cessation of the drug. The (R,R)- enantiomer has greater activity than the (S,S)-isomer but this is tumor line dependent, e.g., there was no difference found for P-388 or Sarcoma 180. Clinical drug administration based on circadium timing showed it was better tolerated when given 16 h after the onset of light. Oxaliplatin binds to guanineN7 and can lead to bidentate chelation that results in the bending of DNA. This feature is recognized by high mobility group proteins (HMG) which impedes repair reactions and stops replication and transcription.

Chemical Properties

White Crystalline Solid


Bebiopharm (Switzerland)


Third generation platinum complex. An antitumor agent with activity against colorectal cancer. Cytotoxicity follows the formation of adducts with DNA. Antineoplastic.




A potent anti-neoplastic agent that binds to DNA and shows efficacy in Cisplatin resistant cell lines


Oxaliplatin is a platinum-based antineoplastic agent that functions by forming DNA adducts specifically in cancer cells, preventing DNA replication and transcription which leads to cell death. Oxaliplatin has cytotoxic effects in a broad range of cell lines, including colon, ovarian, and lung cancer, with IC50 values ranging from 0.5-240, 0.12-19.8, and 2.6-6.1 μM, respectively. Through its general cytotoxic effects, oxaliplatin has anti-tumor activity against advanced colorectal cancer and is typically administered with fluorouracil and leucovorin in a combination known as FOLFOX.


A antitumor agent with activity against colorectal cancer. Cytotoxicity follows the formation of adducts with DNA

brand name

Eloxatin (Sanofi Aventis).

General Description

Oxaliplatin is available in 50- and 100-mg vials for IV administrationin the treatment of ovarian cancer, metastaticcolorectal cancer, and early stage colon cancer in combinationwith 5-fluorouracil/leucovorin. The activation of theagent occurs in low-chloride environments to give theaquated species, which subsequently reacts with DNA in amanner similar to cisplatin. The mechanisms of resistance aresimilar for the two agents; however, oxaliplatin is not recognizedby MMR enzymes and does not show cross-resistancewith cisplatin. The agent is widely distributed, highly proteinbound (85%–88%), and irreversibly binds to erythrocytes.Numerous metabolites have been identified many of whichare produced as a result of nonenzymatic processes and includechloro-, dichloro-, monoaquo-, and diaquo-species.The parent and metabolites are eliminated primarily in theurine with a long terminal elimination half-life of 240 hours.Neurotoxicity is dose limiting and normally presents as peripheralneuropathy, which may be exacerbated by exposureto low temperatures. The neurotoxicity is normally reversiblein contrast to that seen with cisplatin, which may be irreversible.Other adverse effects include nausea, vomiting, diarrhea,myelosuppression, and hypersensitivity reactions.Ototoxicity and renal toxicity occur only rarely in contrast tocisplatin.

Biological Activity

Antitumor agent that forms platinum-DNA adducts. Causes intra- and interstrand DNA crosslinks blocking DNA replication and transcription. Displays higher cytotoxicity and lower nephrotoxicity than analog cisplatin (cis-Diaminodichloroplatinum ) and shows antitumor activity in cell lines with acquired cisplatin resistance.

Oxaliplatin Preparation Products And Raw materials

Raw materials

Preparation Products

Oxaliplatin Suppliers

Global( 325)Suppliers
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Jiangsu Yew Pharmaceutical Co., Ltd.
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View Lastest Price from Oxaliplatin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-07-05 Oxaliplatin
US $10.00 / KG 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.
2018-07-26 Oxaliplatin
US $2000.00 / KG 1KG 98% 100KG career henan chemical co
2018-07-26 Oxaliplatin
US $10.00 / KG 10UG 99% 1000kg/ment Hebei Chisure Biotechnology Co., Ltd.

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