Propofol manufacturers and suppliers

Propofol suppliers

Properties

Melting point:: 18 °C (lit.)

Boiling point:: 256 °C/764 mmHg (lit.)

Density: 0.962 g/mL at 25 °C (lit.)

vapor pressure: 5.6 mm Hg ( 100 °C)

refractive index: n20/D 1.514(lit.)

Flash point:: >230 °F

storage temp.: 2-8°C

solubility: Very slightly soluble in water, miscible with hexane and with methanol

pka: pKa 11.10(H2O,t =20)(Approximate)

color: Pale Yellow to Yellow

Odor: at 100.00?%. mild phenolic

Water Solubility: Very slightly soluble in water.

Merck: 14,7834

BRN: 1866484

InChIKey: OLBCVFGFOZPWHH-UHFFFAOYSA-N

LogP: 3.790

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302-H315-H319-H335

Precautionary statements: P261-P264-P270-P301+P312-P302+P352-P305+P351+P338

Hazard Codes: Xn,T,F

Risk Statements: 22-36/37/38-20/21/22-39/23/24/25-23/24/25-11

Safety Statements: 26-36/37/39-37/39-36-45-36/37-16-7

RIDADR: 2810

WGK Germany: 3

RTECS: SL0810000

TSCA: Yes

HazardClass: 6.1(b)

PackingGroup: III

HS Code: 29089990

Toxicity: dog,LD50,intravenous,30mg/kg (30mg/kg),Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 38, Pg. 1117, 1996.

Use

Propofol is an injectable sedative–hypnotic used for the inductionand maintenance of anesthesia or sedation. Propofolis only slightly soluble in water with an octanol/water partitioncoefficient of 6,761:1; thus, it is formulated as an oil-inwateremulsion. The fat component of the emulsion consistsof soybean oil, glycerol, and egg lecithin. The pKa of thepropanol hydroxyl is 11 and the injectable emulsion has apH of 7 to 8.5. Formulations contain either disodium ethylenediaminetetraaceticacid (EDTA) (0.005%) or sodiummetabisulfite to retard the growth of microorganisms. EDTAis a metal chelator and patients on propofol containingEDTA for extended periods of time excrete more zinc andiron in their urine. The clinical consequence of this is notknown but the manufacturer recommends that a drug holidayor zinc supplementation be considered after 5 days of therapy.

You can find Propofol suppliers, manufacturers, and distributors from countries such as China, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.