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Propofol

Propofol
Propofol structure
CAS No.
2078-54-8
Chemical Name:
Propofol
Synonyms
Anepol;Ivofol;PD18215;AMpofol;Aquafol;Recofol;DIPRIVAN;Dipravan;Fresofol;NSC 5105
CBNumber:
CB4101882
Molecular Formula:
C12H18O
Formula Weight:
178.27
MOL File:
2078-54-8.mol

Propofol Properties

Melting point:
18 °C(lit.)
Boiling point:
256 °C764 mm Hg(lit.)
Density 
0.962 g/mL at 25 °C(lit.)
vapor pressure 
5.6 mm Hg ( 100 °C)
refractive index 
n20/D 1.514(lit.)
Flash point:
>230 °F
storage temp. 
0-6°C
solubility 
Very slightly soluble in water, miscible with hexane and with methanol
form 
neat
pka
pKa 11.10(H2O,t =20)(Approximate)
Water Solubility 
Very slightly soluble in water.
Merck 
14,7834
BRN 
1866484
InChIKey
OLBCVFGFOZPWHH-UHFFFAOYSA-N
CAS DataBase Reference
2078-54-8(CAS DataBase Reference)
NIST Chemistry Reference
Phenol, 2,6-bis(1-methylethyl)-(2078-54-8)
EPA Substance Registry System
Phenol, 2,6-bis(1-methylethyl)-(2078-54-8)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,T,F
Risk Statements  22-36/37/38-20/21/22-39/23/24/25-23/24/25-11
Safety Statements  26-36/37/39-37/39-36-45-36/37-16-7
RIDADR  2810
WGK Germany  3
RTECS  SL0810000
TSCA  Yes
HazardClass  6.1(b)
PackingGroup  III
HS Code  29089990
Hazardous Substances Data 2078-54-8(Hazardous Substances Data)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P311 Call a POISON CENTER or doctor/physician.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Propofol price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich D126608 2,6-Diisopropylphenol 97% 2078-54-8 5g $23.3 2018-11-13 Buy
Sigma-Aldrich 56931 2,6-Diisopropylphenol analytical standard 2078-54-8 1ml $59.2 2018-11-13 Buy
Alfa Aesar L06841 2,6-Diisopropylphenol, 97% 2078-54-8 100g $69 2018-11-13 Buy
Alfa Aesar L06841 2,6-Diisopropylphenol, 97% 2078-54-8 25g $21.8 2018-11-13 Buy
Sigma-Aldrich 1572503 Propofol United States Pharmacopeia (USP) Reference Standard 2078-54-8 500mg $352.8 2018-11-23 Buy

Propofol Chemical Properties,Uses,Production

Chemical Properties

Light Yellow Liquid

Uses

A anesthetic used in veterinary medicine

Uses

Propofol is an anesthetic used in veterinary medicine.

brand name

Diprivan (Abraxis);Disoprivan;Disprofol;Rapinovet.

World Health Organization (WHO)

Propofol, a short acting injectable anaesthetic, was introduced in 1987. In April 1992, the Norwegian Medicines Control Board reported that prolonged use of propofol had been associated with two fatalities in children characterized by metabolic acidosis, liver enlargement, and cerebral oedema. The UK Committee on the Safety of Medicines has received 5 reports of deaths occurring in children who had received propofol while in intensive care.

General Description

Propofol is an injectable sedative–hypnotic used for the inductionand maintenance of anesthesia or sedation. Propofolis only slightly soluble in water with an octanol/water partitioncoefficient of 6,761:1; thus, it is formulated as an oil-inwateremulsion. The fat component of the emulsion consistsof soybean oil, glycerol, and egg lecithin. The pKa of thepropanol hydroxyl is 11 and the injectable emulsion has apH of 7 to 8.5. Formulations contain either disodium ethylenediaminetetraaceticacid (EDTA) (0.005%) or sodiummetabisulfite to retard the growth of microorganisms. EDTAis a metal chelator and patients on propofol containingEDTA for extended periods of time excrete more zinc andiron in their urine. The clinical consequence of this is notknown but the manufacturer recommends that a drug holidayor zinc supplementation be considered after 5 days of therapy.

Biological Activity

Intravenous general anesthetic and hypnotic with a mode of action which includes potentiation of GABA-mediated inhibitory synaptic transmission, direct activation of the GABA A receptor and inhibition of glutamate receptor mediated excitatory synaptic transmission. Also potentiates P2X 4 receptor-mediated currents in P2X 4 -HEK293 cells.

Clinical Use

Generic formulations of propofol may contain sodiummetabisulfite as the antimicrobial agent, and patients allergicto sulfites, especially asthmatic patients, should avoid thisformulation. Aseptic technique must be followed and unusedportions of the drug must be discarded according to the manufacturer’s instructions to prevent microbial contaminationand possible sepsis.

Safety Profile

Poison by intravenous and intraperitoneal routes. Experimental reproductive effects. Combustible when exposed to heat or flame; can react with oxidizing materials. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and fumes. See also PHENOL

Propofol Preparation Products And Raw materials

Raw materials

Preparation Products


Propofol Suppliers

Global( 258)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Liaoning Benyuan Pharmaceutical Co., Ltd
024-45627555
024-45627566 sales@benyuanpharm.com China 62 50
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22043 58
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1530 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20786 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32651 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 bruce@xrdchem.cn CHINA 552 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 16534 60
Jinan Jianfeng Chemical Co., Ltd
15562555968
info@pharmachemm.com CHINA 617 58
GIHI CHEMICALS CO.,LIMITED
08657186217390
sales@gihichemicals.com CHINA 314 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 24118 58

View Lastest Price from Propofol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-04 Propofol
2078-54-8
US $323.60 / KG 5KG 97% 100KG career henan chemical co
2018-04-12 Disoprofol
2078-54-8
US $10.00 / KG 10G 99% 10MT Hubei XinRunde Chemical Co., Ltd.

Propofol Spectrum


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