SERTINDOLE manufacturers and suppliers

SERTINDOLE suppliers

Properties

Melting point:: 95-100°C

Boiling point:: 592.1±50.0 °C(Predicted)

Density: 1.36

storage temp.: Sealed in dry,2-8°C

solubility: DMSO: >10mg/mL

form: solid

pka: 14.53±0.20(Predicted)

color: off-white

Merck: 14,8466

InChIKey: GZKLJWGUPQBVJQ-UHFFFAOYSA-N

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H315-H319-H335-H413

Precautionary statements: P261-P305+P351+P338

Hazard Codes: Xi

Risk Statements: 36/37/38

Safety Statements: 26

WGK Germany: 3

RTECS: NJ0621100

HS Code: 2933.99.6100

Use

Serdolect was launched in the UK for acute and chronic schizophrenia and schizoaffective psychoses. It is synthetically available in three steps from 5chloro-l- (4-fluorophenyl)-l H-indole. Sertindole is selective for the limbic areas of the brain and has a high affinity for the serotinin 5-HT2 receptor where it behaves as an antagonist. It has weak affinity for the α1-adrenergic receptor and no affinity for dopamine D2 receptors. It is as effective as haloperidol but without the extrapyramidal symptoms. This may be a consequence of the fact that it expresses the c-fos protein in a manner different for haloperidol but similar to clozapine. It is non-sedating, long lasting (several days after a single dose) and has an atypical mode of action.

You can find SERTINDOLE suppliers, manufacturers, and distributors from countries such as CHINA, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.