Succimer manufacturers and suppliers

Succimer suppliers

Properties

Melting point:: 196-198 °C (dec.)(lit.)

Boiling point:: 285.62°C (rough estimate)

Density: 1.439 (estimate)

refractive index: 1.5220 (estimate)

storage temp.: -20°C

solubility: DMSO (Sparingly), Methanol (Slightly, Heated)

pka: pK1:2.71;pK2:3.48;pK3:8.89(SH);pK4:10.79(SH) (25°C)

form: Powder

color: White to off-white

Water Solubility: Soluble in water, and ethanol (25 mg/ml, results in colorless to light yellow, clear).

Merck: 14,8865

BRN: 1725150

Stability:: Stable. Combustible. Incompatible with strong oxidizing agents.

InChI: 1S/C4H6O4S2/c5-3(6)1(9)2(10)4(7)8/h1-2,9-10H,(H,5,6)(H,7,8)/t1-,2+

InChIKey: ACTRVOBWPAIOHC-XIXRPRMCSA-N

SMILES: OC(=O)[C@@H](S)[C@@H](S)C(O)=O

CAS DataBase Reference: 304-55-2(CAS DataBase Reference)

EPA Substance Registry System: Butanedioic acid, 2,3-dimercapto-, (2R,3S)-rel- (304-55-2)

Safety Information

Symbol(GHS): GHS07,GHS08

Signal word: Warning

Hazard statements: H315-H319-H335-H361

Precautionary statements: P201-P261-P280-P305+P351+P338-P405-P501a

PPE: Eyeshields, Gloves, type N95 (US)

Hazard Codes: Xi

Risk Statements: 36/37/38

Safety Statements: 24/25-36-26

WGK Germany: 2

RTECS: WM7650000

F: 10-23

TSCA: TSCA listed

HS Code: 29309090

Storage Class: 11 - Combustible Solids

Hazardous Substances Data: 304-55-2(Hazardous Substances Data)

Toxicity: LD50 i.p. in mice: >3000 mg/kg (Friedheim, Corvi)

Use

Succimer is a newly available oral chelator of lead and other heavy metals. The compound is indicated for the treatment of lead poisoning in children. Succimer does not bind iron, calcium or magnesium and preferentially binds lead, mercury and arsenic over copper or zinc. The metal-bound succimer is excreted in the urine. The drug may also be effective in adults.

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